{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:48:23Z","timestamp":1790797703885,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Australas J Ageing"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study examined the correlation between dexmedetomidine and postoperative sleep quality in older patients following intestinal surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 112 older patients were randomly assigned to receive either saline (Group A) or dexmedetomidine (Group B). Sleep quality was evaluated using the Pittsburgh Sleep Quality Index (PSQI) before surgery and on postoperative days 1, 3, 7 and 30. Urinary melatonin and cortisol levels were measured, and pain intensity was assessed using the Visual Analogue Scale (VAS) at various time points. Logistic regression analysis identified factors influencing postoperative sleep quality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both groups showed increased PSQI scores postoperatively, with Group A scoring higher than Group B. Group B exhibited a significantly lower incidence of sleep disorders on Days 1 and 3. Urinary melatonin levels decreased in both groups, with Group A showing lower levels, while cortisol concentrations increased, particularly in Group A. Higher VAS scores were also noted in Group A. Patients not receiving dexmedetomidine had a greater prevalence of sleep disorders. Logistic regression revealed dexmedetomidine dosage, gender and VAS scores at 24\u2009h as significant factors affecting sleep quality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Dexmedetomidine enhances postoperative sleep quality in older patients undergoing intestinal surgery by reducing cortisol levels, increasing melatonin production and effectively alleviating pain, thereby supporting better recovery outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajag.70024","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T07:28:56Z","timestamp":1745306936000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Correlation between dexmedetomidine and postoperative sleep quality in older patients undergoing intestinal surgery"],"prefix":"10.1111","volume":"44","author":[{"given":"Yongjian","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology Central Hospital Affiliated to Shandong First Medical University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Central Hospital Affiliated to Shandong First Medical University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-021-02361-9"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2018.01.008"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000004046"},{"issue":"6","key":"e_1_2_10_5_1","first-page":"635","article-title":"Research advances on the effect of perioperative anesthesia on postoperative sleep","volume":"43","author":"Li L","year":"2022","journal-title":"Int J Anesthesiol Resuscitation"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-019-0439-z"},{"issue":"1","key":"e_1_2_10_7_1","first-page":"52","article-title":"Effect of dexmedetomidine and dezocine in patient\u2010controlled intravenous analgesia on postoperative sleep quality and cognition of elderly patients","volume":"10","author":"Lu FF","year":"2021","journal-title":"Surg Res New Tech"},{"issue":"3","key":"e_1_2_10_8_1","first-page":"278","article-title":"Risk factors for postoperative sleep disturbances in elderly patients undergoing thoracic surgery","volume":"41","author":"Zhang W","year":"2021","journal-title":"Chin J Anesthesiol"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S304162"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2015.12.008"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aew466"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0270095"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/7998104"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000005323"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2022.101630"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00391-020-01707-4"},{"issue":"4","key":"e_1_2_10_17_1","first-page":"661","article-title":"Postoperative sleep disorders in elderly patients","volume":"29","author":"Hua MM","year":"2023","journal-title":"Geriatr Health Care"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.14266"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.15564"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.2147\/NSS.S300803"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-020-01025-7"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.00528"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.28886"},{"issue":"10","key":"e_1_2_10_24_1","first-page":"1002","article-title":"Effects of intraoperative continuous pumping of dexmedetomidine on postoperative sleep quality in patients undergoing spinal surgery","volume":"42","author":"Wang K","year":"2020","journal-title":"J Third Mil Med Univ"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-023-02048-6"},{"issue":"6","key":"e_1_2_10_26_1","first-page":"743","article-title":"The effect of pre\u2010operative sleep quality on post\u2010operative pain and emergence agitation: prospective and cohort study. 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