{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T06:08:43Z","timestamp":1773382123784,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Australas J Ageing"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Frailty, defined as a reduced capacity to manage stress due to multisystem dysfunction, has a significant impact on quality of life, morbidity and mortality. This study aimed to identify the factors influencing the progression to frailty in community\u2010dwelling older adults during the coronavirus disease 2019 (COVID\u201019) pandemic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective observational study included non\u2010frail individuals aged 65\u2009years or older admitted to a geriatric outpatient clinic. Evaluation was conducted before (T0) and after (T1) the pandemic. Logistic regression analysis was performed to examine factors associated with progression to frailty.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The final sample comprised 139 participants (mean age 74.8\u2009\u00b1\u20096.2\u2009years, 60% female). The median follow\u2010up time was 53\u2009months (range, 27\u201360). Thirty\u2010one participants (22%) developed frailty after the pandemic. In the clinical follow\u2010up (T1), a decrease in the Mini Nutritional Assessment\u2010Short Form score was associated with an increased risk of frailty. In the multivariate logistic regression analysis, four or more doses of the COVID\u201019 vaccine, sufficient physical activity and a Mini\u2010Mental State Examination score \u226527 points were associated with a lower risk of transition to frailty, while polypharmacy and age \u226575\u2009years were associated with an increased risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study highlights the importance of full vaccination, along with promoting physical activity, mitigating polypharmacy and enhancing cognitive health to prevent the onset of frailty during a viral pandemic.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajag.70050","type":"journal-article","created":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T16:24:57Z","timestamp":1748795097000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Factors affecting progression to frailty in community\u2010dwelling older adults during all <scp>COVID<\/scp>\u201019 waves"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2176-5315","authenticated-orcid":false,"given":"Ebru","family":"\u00c7akir","sequence":"first","affiliation":[{"name":"Department of Geriatrics, Gulhane Faculty of Medicine and Gulhane Training and Research Hospital University of Health Sciences  Kecioren Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatice Tu\u011fba","family":"Yazir","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Gulhane Faculty of Medicine and Gulhane Training and Research Hospital University of Health Sciences  Kecioren Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"\u00c7etin","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Gulhane Faculty of Medicine and Gulhane Training and Research Hospital University of Health Sciences  Kecioren Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zehra","family":"Sarikaya Demirba\u015f","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Gulhane Faculty of Medicine and Gulhane Training and Research Hospital University of Health Sciences  Kecioren Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Ilkin","family":"Naharci","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Gulhane Faculty of Medicine and Gulhane Training and Research Hospital University of Health Sciences  Kecioren Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6285058"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-019-1179-9"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2010.08.003"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/56.3.M146"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S139860"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11100999"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines11030606"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2020.101205"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(20)30146-8"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s41999-021-00524-1"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afab061"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afx188"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/agm2.12258"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2021.104562"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s41999-022-00740-3"},{"key":"e_1_2_12_17_1","unstructured":"World Health Organization.Statement on the fifteenth meeting of the International Health Regulations (2005) Emergency Committee regarding the coronavirus disease (COVID\u201019) pandemic. 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