{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:15:28Z","timestamp":1772993728367,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Australas J Ageing"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Although existing evidence suggests a potential link between dementia and adverse outcomes in patients with COVID\u201019, a definitive relationship is uncertain. This study aimed to evaluate the impact of dementia on in\u2010hospital outcomes of patients in the presence of COVID\u201019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The US Nationwide Inpatient Sample (NIS) was searched for patients 65\u2009years or older hospitalised for COVID\u201019 in 2020. Patients were categorised into those with and without dementia before COVID\u201019 infection. Outcomes included in\u2010hospital mortality, discharge to long\u2010term care, length of stay (LOS), total hospital costs and complications. Propensity score matching (PSM) was used to balance the baseline characteristics between the groups. Regression analyses were performed to assess the associations between dementia and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After PSM, 42,214 patients were included, with equal distribution of most study variables between groups. Dementia was associated with increased in\u2010hospital mortality (adjusted odds ratio [aOR]\u2009=\u20091.17, 95% confidence interval [CI]: 1.11\u20131.23), discharge to long\u2010term care facilities (aOR\u2009=\u20094.0, 95% CI: 3.8\u20134.2), occurrence of any complications (aOR\u2009=\u20091.33, 95% CI: 1.27, 1.38), 1.12\u2009days longer LOS (95% CI: .93\u20131.31) and 2.68 thousand USD higher total hospital costs (95% CI: .72\u20134.64). For specific complications, dementia was associated with significantly increased risks of acute respiratory distress syndrome (aOR\u2009=\u20091.19, 95% CI: 1.14\u20131.24) encephalitis, myelitis and encephalomyelitis (aOR\u2009=\u20094.60, 95% CI: 1.33\u201315.93), as well as delirium, respiratory failure and acute kidney injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Dementia is associated with worse outcomes of older patients with COVID\u201019.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ajag.70082","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T11:11:26Z","timestamp":1757329886000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of dementia on outcomes in older patients with COVID\u201019: A nationwide inpatient sample analysis"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3205-6530","authenticated-orcid":false,"given":"Ruoh Lih","family":"Lei","sequence":"first","affiliation":[{"name":"Department of Nursing, College of Nursing and Health Welfare National Chi Nan University  Puli Nantou Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Min","family":"Chu","sequence":"additional","affiliation":[{"name":"Division of Family Medicine, Department of Family Medicine Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Department of Post\u2010Baccalaureate Medicine College of Medicine, National Chung Hsing University  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsu\u2010Yin","family":"Wu","sequence":"additional","affiliation":[{"name":"Center for Health Innovations and Studies Eastern Michigan University  Ypsilanti Michigan 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