{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T17:37:48Z","timestamp":1787593068578,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:00:00Z","timestamp":1760140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Australas J Ageing"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to examine the prevalence of frailty in hospitalised older patients with atrial fibrillation (AF) and its relationship with oral anticoagulant (OAC) prescription during admission. The secondary aim was to examine the association between frailty and rate\u2010\/rhythm\u2010control medication prescriptions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective observational study included adults aged 65\u2009years or older with AF admitted to six hospitals in Australia in 2022. Frailty was defined by a Frailty Index \u2265\u20090.25. Logistic regression models were applied to examine the association between frailty and the prescriptions of OAC, rate\u2010control and rhythm\u2010control drugs during hospitalisation. Results are presented as odds ratios (OR) and 95% confidence intervals (CI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were 685 patients, with a mean age of 82.6 (SD 8.3), 50% female and 43% identified as frail. Overall, 76% were prescribed OAC (68% in the frail versus 81% in the non\u2010frail,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), 38% received rate\u2010control drugs (42% in the frail vs. 34% in the non\u2010frail,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04), 27% received rhythm\u2010control drugs (23% in the frail vs. 31% in the non\u2010frail,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). The adjusted ORs of frailty on prescriptions were 0.58 (95% CI 0.39\u20130.86) for OAC, 1.75 (95% CI 1.22\u20132.52) for rate\u2010control drugs and 0.83 (95% CI 0.55\u20131.24) for rhythm\u2010control drugs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The study revealed a high prevalence of frailty in older inpatients with AF. Frailty was associated with reduced likelihood of prescription of OAC and increased likelihood of prescribing rate\u2010control medications, with no independent impact on rhythm\u2010control therapy. Further studies are needed to understand these prescribing patterns.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ajag.70101","type":"journal-article","created":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:49:16Z","timestamp":1760176156000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Frailty in Older Patients With Atrial Fibrillation and Its Relationship With Anticoagulant Use: A Multi\u2010Centred Observational Study in New South Wales"],"prefix":"10.1111","volume":"44","author":[{"given":"Tu N.","family":"Nguyen","sequence":"first","affiliation":[{"name":"The George Institute for Global Health  Sydney New South Wales Australia"},{"name":"Sydney School of Public Health The University of Sydney  Sydney New South Wales 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