{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T11:49:53Z","timestamp":1782560993688,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T00:00:00Z","timestamp":1781395200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Australas J Ageing"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>There appear to be no definitive guidelines on optimal prevention and management of acute phase responses (APRs) following intravenous bisphosphonates (IVBP) for osteoporosis. Our objective was to identify physician prescribing practices for supplementary therapy aimed at managing APRs and whether these were thought beneficial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      An online survey was distributed to members of key Australian societies for geriatrics, rheumatology and endocrinology (membership\n                      <jats:italic>n<\/jats:italic>\n                      \u2009\u2248\u20092900) with questions assessing if respondents prescribed IVBP, their experience managing APRs including medications used and whether these were beneficial.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seventy\u2010five responses were collected from geriatricians, endocrinologists and rheumatologists, with 68 respondents prescribing IVBP for osteoporosis. Overall, 84% (57\/68) of those using IVBP previously managed a post\u2010IVBP APR and 24% (16) reported risk of APR could influence their prescribing. Eighty\u2010eight percent (60) of those using IVBP reported using paracetamol for APR management, whereas 41% (28) used NSAIDs and 53% (36) used corticosteroids. There was considerable variability in reported prescribing plans. Only 50% (30) of clinicians using paracetamol and 42% (11) of those using NSAIDs reported finding these beneficial for APR management, whereas 92% (33) of those using corticosteroids reported observing benefit. Ninety\u2010four per cent (34) of clinicians prescribing corticosteroids did so on a case\u2010by\u2010case basis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Despite limited numbers, the results of this pilot work indicated clinicians used various medications to offset post\u2010IVBP APRs and some reported that they had observed benefit in terms of APR prevention or treatment, supporting the need for further clinical trials to establish which, if any, are associated with improved clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ajag.70195","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T03:54:40Z","timestamp":1781495680000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessing Clinician Prescribing Practices for Prophylaxis and Treatment of Acute Phase Responses Following\n                    <scp>IV<\/scp>\n                    Bisphosphate Infusions for Osteoporosis: A Pilot Survey\u2010Based Study"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8208-0115","authenticated-orcid":false,"given":"Stephen","family":"Sweeney","sequence":"first","affiliation":[{"name":"Liverpool Hospital South Western Sydney LHD  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"El\u2010Haddad","sequence":"additional","affiliation":[{"name":"Liverpool Hospital South Western Sydney LHD  Sydney New South Wales Australia"},{"name":"South Western Sydney Clinical School UNSW  Sydney New South Wales Australia"},{"name":"Western Sydney University School of Medicine WSU  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7711-9718","authenticated-orcid":false,"given":"Danielle N\u00ed","family":"Chr\u00f3in\u00edn","sequence":"additional","affiliation":[{"name":"Liverpool Hospital South Western Sydney LHD  Sydney New South Wales Australia"},{"name":"South Western Sydney Clinical School UNSW  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,14]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Osteoporosis and Fractures in Australia: A Burden of Disease Analysis, 2023 to 2033","author":"Mudiyanselage S. B.","year":"2024"},{"key":"e_1_2_9_3_1","volume-title":"Hip Fracture Care Pathways in Australia","author":"Australian Institute of Health and Welfare","year":"2023"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa048"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/ejhpharm\u20102017\u2010001258"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010\u20100597"},{"key":"e_1_2_9_7_1","volume-title":"Bisphosphonate","author":"Ganesan K.","year":"2025"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198\u2010011\u20101881\u2010x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11657\u2010020\u201000733\u20104"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198\u2010011\u20101563\u20108"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4802"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11657\u2010024\u201001452\u2010w"},{"key":"e_1_2_9_13_1","unstructured":"Australian and New Zealand Society for Geriatric Medicine \u201c2024 Annual Report\u201d(2025) https:\/\/anzsgm.org\/2024\u2010annual\u2010report\/."},{"key":"e_1_2_9_14_1","unstructured":"Endocrine Society of Australia \u201cEndocrine Society of Australia 2025 Annual Report\u201d(Endocrine Society of Australia 2025) https:\/\/www.endocrinesociety.org.au\/downloads\/Endocrine%20Society%20of%20Australia%202025%20Annual%20Report.pdf."},{"key":"e_1_2_9_15_1","unstructured":"Australian Rheumatology Association \u201cARA Annual Achievement Report 2025\u201d(2025) https:\/\/rheumatology.org.au\/Portals\/2\/Documents\/Public\/About_the_ARA\/ARA_AnnualAchievementReport\u20102025%20\u2010%202026\u201002\u201020%20FINAL_v2.pdf."},{"key":"e_1_2_9_16_1","unstructured":"Australian and New Zealand Hip Fracture Registry \u201cAnnual Report of Hip Fracture Care 2025 \u201d(ANZHFR; 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