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However, the dose\u2013response relationship between physical activity (PA) and IC decline is unclear. The objective of this study was to examine the dose\u2013response relationship between PA and IC decline in hospitalised older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional study was conducted from August 2024 to July 2025, with hospitalised older patients recruited from three tertiary hospitals in Gansu Province, China. Data were collected using a general information questionnaire, the IC Assessment Scale and the International Physical Activity Questionnaire\u2010Short Form (IPAQ\u2010SF). Binary logistic regression and restricted cubic spline (RCS) models were used to explore the association between PA and IC decline, adjusting for potential confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The final analyses included a total of 534 hospitalised older patients. Using the low PA group as the reference, the moderate PA group was associated with a 66% lower likelihood of IC decline (OR\u2009=\u20090.34, 95% CI: 0.23\u20130.50), and the high PA group was associated with a 74% lower likelihood (OR\u2009=\u20090.26, 95% CI: 0.14\u20130.49). In the RCS analysis, a J\u2010shaped nonlinear association was observed between PA levels and IC decline. Subgroup analyses by sex indicated that sex may serve as a potential moderator in the association between PA and IC decline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study revealed a J\u2010shaped nonlinear association between PA and the likelihood of IC decline, with moderately higher PA levels associated with a lower likelihood of IC decline.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ajag.70230","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T10:23:51Z","timestamp":1790850231000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dose\u2013Response Relationship Between Physical Activity and Intrinsic Capacity Decline Among Hospitalised Older Patients"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3553-2829","authenticated-orcid":false,"given":"Wanting","family":"Fan","sequence":"first","affiliation":[{"name":"School of Nursing Lanzhou University  Lanzhou City Gansu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8710-1820","authenticated-orcid":false,"given":"Qiuxia","family":"Qian","sequence":"additional","affiliation":[{"name":"School of Nursing Lanzhou University  Lanzhou City Gansu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lirong","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Nursing Lanzhou University  Lanzhou City Gansu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0655-4047","authenticated-orcid":false,"given":"Zhenzhen","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Nursing Lanzhou University  Lanzhou City Gansu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanhuan","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Nursing Lanzhou University  Lanzhou City Gansu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8528-8769","authenticated-orcid":false,"given":"Tian","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Nursing Lanzhou University  Lanzhou City Gansu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidan","family":"Li","sequence":"additional","affiliation":[{"name":"School of Nursing Lanzhou University  Lanzhou City Gansu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ailing","family":"Yang","sequence":"additional","affiliation":[{"name":"The Orthopedics Department of the Second Hospital of Lanzhou University  Lanzhou City Gansu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0135-9923","authenticated-orcid":false,"given":"Yuxia","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Nursing Lanzhou University  Lanzhou City Gansu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"World Population Prospects 2019: Highlights","author":"United Nations","year":"2019"},{"key":"e_1_2_11_3_1","unstructured":"\u201cCircular on Issuing the 14th Five\u2010Year Plan for Healthy Aging \u201dBulletin of the National Health Commission of the People's Republic of China (2022) 2: 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