{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T17:39:53Z","timestamp":1778780393489,"version":"3.51.4"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,8,2]],"date-time":"2013-08-02T00:00:00Z","timestamp":1375401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Recurrence rates of oral cancer following primary treatment have been reported in the range of 25\u201348%. However, salvage therapy remains a critical challenge to improving outcomes. Here, we investigated prognostic factors and outcomes for salvage surgery in patients with recurrent oral tongue squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">OTSCC<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed patients who were referred to <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ichi <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ancer <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>enter, <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apan, for the treatment of recurrent <jats:styled-content style=\"fixed-case\">OTSCC<\/jats:styled-content>. All patients included in the present study had undergone salvage surgery. Data to identify the predictive value of prognostic factors were available from 69 patients. Prognostic factors were assessed using <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ox's proportional hazards regression analysis. Differences in overall survival between groups of patients were assessed by the log\u2013rank test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 36 patients (52%) developed second recurrence or died, of which 21 (58%) occurred within 12 months of salvage surgery. Univariate analysis indicated that survival was significantly worse in patients with recurrent stage <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> tumors, two or more positive cervical lymph nodes, levels <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content> positive cervical lymph nodes, extracapsular spread (<jats:styled-content style=\"fixed-case\">ECS<\/jats:styled-content>) of positive cervical lymph nodes and a disease\u2010free interval from initial treatment of less than 12 months. On multivariate analysis, <jats:styled-content style=\"fixed-case\">ECS<\/jats:styled-content> was an independent prognostic factor for overall survival after salvage surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Neck status at the time of salvage surgery, particularly <jats:styled-content style=\"fixed-case\">ECS<\/jats:styled-content> is a significant prognostic factor for surgical salvage. Survival was also influenced by the stage of the recurrent tumor and disease\u2010free interval, suggesting that the biological features of recurrent tumors might impact on prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.12087","type":"journal-article","created":{"date-parts":[[2013,8,2]],"date-time":"2013-08-02T09:57:53Z","timestamp":1375437473000},"source":"Crossref","is-referenced-by-count":19,"title":["Prognostic factors and outcomes for salvage surgery in patients with recurrent squamous cell carcinoma of the tongue"],"prefix":"10.1111","volume":"12","author":[{"given":"Mitsuo","family":"Goto","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Aichi Gakuin University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhiro","family":"Hanai","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Aichi Cancer 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