{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:08:25Z","timestamp":1790784505019,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,8,5]],"date-time":"2013-08-05T00:00:00Z","timestamp":1375660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"crossref","award":["81202149"],"award-info":[{"award-number":["81202149"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Suzhou Science and Technology Program","award":["SYS201117"],"award-info":[{"award-number":["SYS201117"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Little is known about the relationship between <jats:styled-content style=\"fixed-case\">XRCC1<\/jats:styled-content> Codon399 polymorphisms and radiotherapy (<jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>) outcomes in patients with nasopharyngeal carcinoma (<jats:styled-content style=\"fixed-case\">NPC<\/jats:styled-content>). We aimed to investigate whether <jats:styled-content style=\"fixed-case\">XRCC1<\/jats:styled-content> Codon399 polymorphisms were correlated to treatment efficacy and normal tissue toxicity in <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hinese patients with locally advanced <jats:styled-content style=\"fixed-case\">NPC<\/jats:styled-content> after <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty eligible patients with <jats:styled-content style=\"fixed-case\">NPC<\/jats:styled-content> stage <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">IVa<\/jats:styled-content> were recruited. Patients received definitive <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>, 66\u201376\u2009Gy. One cycle neoadjuvant chemotherapy with docetaxel and cisplatin regimen was used before <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>, two or three cycles for concurrent chemo\u2010RT followed by two to four cycles adjuvant chemotherapy with the same regimen. Before the treatment, <jats:styled-content style=\"fixed-case\">XRCC1<\/jats:styled-content> Codon399 polymorphisms were determined by polymerase chain reaction based ligase detection reaction methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six of 60 <jats:styled-content style=\"fixed-case\">NPC<\/jats:styled-content> patients were homozygous for <jats:styled-content style=\"fixed-case\">XRCC1 C<\/jats:styled-content>odon399 <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>ln\/<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>ln and 35% were heterozygous. The expressions of genotypes were unrelated to gender, age, clinical stage, <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> stage or <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content> stage. Codon399 <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>ln\/<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>ln allele correlated with a higher medium\u2010term tumor regression ratio after <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content> for primary nasopharyngeal neoplasm and metastatic lymph nodes (&gt;80% <jats:italic>vs<\/jats:italic> 40\u201360%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). Compared with other two genotypes, patients with <jats:styled-content style=\"fixed-case\">XRCC1 C<\/jats:styled-content>odon399 <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>ln\/<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>ln allele were more likely to obtain complete remission of tumor (100% <jats:italic>vs<\/jats:italic> 76 and 67%, <jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). No correlation between <jats:styled-content style=\"fixed-case\">XRCC1 C<\/jats:styled-content>odon399 polymorphisms and acute or late radiation\u2010induced injury of normal tissues was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">XRCC1 C<\/jats:styled-content>odon399 <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>ln\/<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>ln allele may be associated with better tumor regression, and is suggested as a promising predictive factor for outcome for locally advanced <jats:styled-content style=\"fixed-case\">NPC<\/jats:styled-content>. Further study with larger samples and long\u2010time follow\u2010up is needed for accurate assessment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.12117","type":"journal-article","created":{"date-parts":[[2013,8,5]],"date-time":"2013-08-05T10:04:59Z","timestamp":1375697099000},"source":"Crossref","is-referenced-by-count":18,"title":["Significance of <scp>XRCC1 C<\/scp>odon399 polymorphisms in <scp>C<\/scp>hinese patients with locally advanced nasopharyngeal carcinoma treated with radiation therapy"],"prefix":"10.1111","volume":"12","author":[{"given":"Xiao\u2010Ming","family":"Zhai","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology The first Affiliated Hospital of Soochow University  Suzhou China"},{"name":"School of Radiation Medicine and Protection Medical College of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun\u2010Chao","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Suzhou Municipal Hospital (East Branch)  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Suzhou Municipal Hospital (East Branch)  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010Ping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The first Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2010Ning","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The first Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The first Affiliated Hospital of Soochow University  Suzhou China"},{"name":"Department of Nuclear Medicine The first Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1044579X02000858"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.4.1310"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.06.158"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji084"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.16.790"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(01)02690-6"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(01)00822-9"},{"key":"e_1_2_6_9_1","first-page":"119","article-title":"Polymorphisms of the DNA repair gene XRCC 1 and lung cancer risk","volume":"10","author":"Ratnasinghe D","year":"2001","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10528"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(00)00537-1"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5446.1897"},{"key":"e_1_2_6_13_1","first-page":"604","article-title":"Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans","volume":"58","author":"Shen MR","year":"1998","journal-title":"Cancer Res"},{"key":"e_1_2_6_14_1","first-page":"2329","article-title":"XRCC1 polymorphisms and risk of nasopharyngeal carcinoma: a meta\u2010analysis","volume":"12","author":"Huang GL","year":"2011","journal-title":"Asian Pacific J Cancer Prev"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.6632"},{"key":"e_1_2_6_16_1","first-page":"1168","article-title":"Polymorphisms in the DNA repair gene XRCC1, breast cancer risk, and response to radiotherapy","volume":"12","author":"Moullan N","year":"2003","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.12.027"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.06.037"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.10.12.6160"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/22.4.593"},{"key":"e_1_2_6_21_1","first-page":"125","article-title":"DNA repair gene XRCC1 polymorphisms, smoking, and bladder cancer risk","volume":"10","author":"Stern MC","year":"2001","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5718(02)00127-4"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1568-7864(03)00085-5"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/22.6.917"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.07.951"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2003.09.010"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(02)00079-8"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2007.02.019"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/0955300021000045673"}],"container-title":["Asia-Pacific Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajco.12117","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajco.12117","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajco.12117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T11:48:01Z","timestamp":1694346481000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajco.12117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,5]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1111\/ajco.12117"],"URL":"https:\/\/doi.org\/10.1111\/ajco.12117","archive":["Portico"],"relation":{},"ISSN":["1743-7555","1743-7563"],"issn-type":[{"value":"1743-7555","type":"print"},{"value":"1743-7563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,5]]}}}