{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:13:56Z","timestamp":1761059636378},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,2]],"date-time":"2013-12-02T00:00:00Z","timestamp":1385942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate pathological factors for prognosis, intravesical recurrence and distant metastasis of upper urinary tract cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This clinical study included 105 patients with renal pelvic and ureteral cancer who were treated at the <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>ochi <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>edical <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>chool <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ospital between 1982 and 2008. Of these patients, 90 who underwent nephroureterectomy were analyzed for pathological risk factors using uni\u2010 and multivariate analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean follow\u2010up period of the 105 patients was 53 months. The disease\u2010specific survival rates were 70% and 62% at 3 and 5 years. Twenty\u2010three patients (23%) developed intravesical recurrence, and the mean and median times to recurrence were 18.8 and 9.2 months, respectively. Seventeen patients (19%) had distant metastasis, and the mean and median times to distant metastasis were 25.2 and 25.3 months, respectively. Multivariate analysis identified the pathological grade as an independent risk factor for prognosis (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.031), age (\u226567 years) and tumor diameter (\u22653\u2009cm) as independent risk factors for intravesical recurrence (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.007 and 0.003, respectively), and the pathological grade (<jats:styled-content style=\"fixed-case\">G1<\/jats:styled-content>,2 <jats:italic>vs<\/jats:italic>\u2005<jats:styled-content style=\"fixed-case\">G3<\/jats:styled-content>) and lymphatic invasion as independent risk factors for distant metastasis (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009=\u20090.006 and 0.003, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with higher\u2010grade upper urinary tract cancer show a poor prognosis, and often develop distant metastasis, suggesting the need for careful postoperative follow\u2010up. Those with lymphatic invasion or tumors of 3\u2009cm or more in diameter frequently develop intravesical recurrence and distant metastasis, respectively, indicating the need for strict follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.12155","type":"journal-article","created":{"date-parts":[[2013,12,2]],"date-time":"2013-12-02T08:20:45Z","timestamp":1385972445000},"source":"Crossref","is-referenced-by-count":4,"title":["Pathological risk factors in upper urinary tract cancer"],"prefix":"10.1111","volume":"12","author":[{"given":"Tsutomu","family":"Shimamoto","sequence":"first","affiliation":[{"name":"Department of Urology Kochi University  Nankoku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Urology Kochi University  Nankoku 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