{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:57:42Z","timestamp":1761155862716},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,10,31]],"date-time":"2014-10-31T00:00:00Z","timestamp":1414713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2017,4]]},"abstract":"Abstract<\/jats:title>Aims<\/jats:title>We examined the risk factors and prognostic factors for synchronous esophageal neoplasia (SEN<\/jats:styled-content>) by comparing the characteristics of hypopharyngeal cancer (HPC<\/jats:styled-content>) patients with and without SEN<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>We examined 183 patients who were treated with definitive radiotherapy for HPC<\/jats:styled-content>. Lugol chromoendoscopy screening of the esophagus was performed in all patients before chemoradiotherapy.<\/jats:p><\/jats:sec>Results<\/jats:title>Thirty\u2010six patients had SEN<\/jats:styled-content>, 49 patients died of HPC<\/jats:styled-content> and two died of esophageal cancer. The patients with SEN<\/jats:styled-content> exhibited significantly higher alcohol consumption than those without SEN<\/jats:styled-content> (P<\/jats:italic>\u2009=\u20090.018). The 5\u2010year overall survival (OS) rate of the 36 patients with SEN<\/jats:styled-content> was lower than that of the other patients (36.2% vs<\/jats:italic> 63.4%, P<\/jats:italic>\u2009=\u20090.006). The SEN<\/jats:styled-content> patients exhibited significantly shorter HPC<\/jats:styled-content> cause\u2010specific survival than the other patients (P<\/jats:italic>\u2009=\u20090.039). Both the OS<\/jats:styled-content> (P<\/jats:italic>\u2009=\u20090.005) and the HPC<\/jats:styled-content> cause\u2010specific survival (P<\/jats:italic>\u2009=\u20090.026) of the patients with SEN<\/jats:styled-content> were significantly shorter than those of the patients without SEN<\/jats:styled-content> in multivariate analysis. Category 4\/T<\/jats:styled-content>1 stage esophageal cancer was treated with concurrent chemoradiotherapy (CCRT<\/jats:styled-content>), endoscopic treatment or chemotherapy. The 5\u2010year survival rates for esophageal cancer recurrence for CCRT<\/jats:styled-content>, endoscopic treatment and chemotherapy were 71.5, 43.7 and 0%, respectively. The median (range) survival time (months) of CCRT<\/jats:styled-content>, endoscopic treatment and chemotherapy was 22.7 (7.5\u201390.6), 46.44 (17.3\u2013136.7) and 7.98 (3.72\u201322.8), respectively.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Advanced HPC<\/jats:styled-content> patients with SEN<\/jats:styled-content> might have a poorer prognosis than those without SEN<\/jats:styled-content> even when the esophageal cancer is detected early and managed appropriately.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.12274","type":"journal-article","created":{"date-parts":[[2014,10,31]],"date-time":"2014-10-31T05:12:46Z","timestamp":1414732366000},"source":"Crossref","is-referenced-by-count":10,"title":["Impact of the early detection of esophageal neoplasms in hypopharyngeal cancer patients treated with concurrent chemoradiotherapy"],"prefix":"10.1111","volume":"13","author":[{"given":"Shigenobu","family":"Watanabe","sequence":"first","affiliation":[{"name":"Department of Radiation 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