{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T22:02:10Z","timestamp":1764540130174},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,10,31]],"date-time":"2014-10-31T00:00:00Z","timestamp":1414713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>In multiple myeloma (MM<\/jats:styled-content>), the growth and survival of myeloma cells is controlled by interleukin\u20106 (IL<\/jats:styled-content>\u20106), the plasma levels of which is controlled by a guanine\/cytosine substitution occurring in position \u2010174 of IL<\/jats:styled-content>\u20106 gene promoter region. We studied the occurrence of IL<\/jats:styled-content>\u20106\u2010174 G<\/jats:styled-content>\/C<\/jats:styled-content> polymorphism in patients of MM<\/jats:styled-content> and correlated the presence of genotypes with serum IL<\/jats:styled-content>\u20106 levels and tumor staging.<\/jats:p><\/jats:sec>Methods<\/jats:title>One hundred three patients with MM and 117 age\u2010 and sex\u2010matched healthy controls were staged by International Staging System. IL<\/jats:styled-content>\u20106 genotypes were evaluated by polymerase chain reaction and restriction enzyme analysis. Serum levels of IL<\/jats:styled-content>\u20106 were assessed by enzyme\u2010linked immunosorbent assay.<\/jats:p><\/jats:sec>Results<\/jats:title>Frequency of GG<\/jats:styled-content>, GC<\/jats:styled-content> and CC<\/jats:styled-content> genotypes did not differ significantly between cases (GG<\/jats:styled-content> 52%, GC<\/jats:styled-content> 40%, CC<\/jats:styled-content> 9%) and controls. The median serum level of IL<\/jats:styled-content>\u20106 was significantly higher among the GC<\/jats:styled-content> genotype versus other genotypes (24\u2009ng\/mL, P<\/jats:italic>\u2009=\u20090.007) as compared with the GG<\/jats:styled-content> versus other genotypes (12\u2009ng\/mL, P<\/jats:italic>\u2009=\u20090.001). GC was associated more with stage 3 disease (27%) than was GG (11%) or CC<\/jats:styled-content> (22% P<\/jats:italic>\u2009=\u20090.001).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>At position 174 of the IL\u20106 promoter, patients with GC<\/jats:styled-content> genotype had higher serum levels of IL<\/jats:styled-content>\u20106 and presented with more severe disease compared with patients with GG<\/jats:styled-content> or CC<\/jats:styled-content> genotype.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.12290","type":"journal-article","created":{"date-parts":[[2014,10,31]],"date-time":"2014-10-31T05:13:37Z","timestamp":1414732417000},"source":"Crossref","is-referenced-by-count":13,"title":["Interleukin\u20106 gene\u2010174 G<\/scp>\/C<\/scp> promoter polymorphism and its association with clinical profile of patients with multiple myeloma"],"prefix":"10.1111","volume":"13","author":[{"given":"Baidarbhi","family":"Chakraborty","sequence":"first","affiliation":[{"name":"Department of Biochemistry Dr. D.Y. Patil Medical College Navi Mumbai Maharashtra India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaurav","family":"Vishnoi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Maulana Azad Medical College Delhi New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srinivas H","family":"Gowda","sequence":"additional","affiliation":[{"name":"Department of Biochemistry AIIMS Delhi New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binita","family":"Goswami","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Lady Hardinge Medical College Delhi New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,10,31]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2311020452"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra041875"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.308.6935.1033"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190902856832"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V91.1.3"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.1388"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11072"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M000379200"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.9.12.5537"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.10.11.5736"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.33.19643"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.242"},{"key":"e_1_2_5_14_1","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1210\/jcem.85.3.6555","article-title":"Interleukin\u20106 gene polymorphism and lipid abnormalities in healthy subjects","volume":"85","author":"Fernandez\u2010real JM","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.8.13.8985"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2007.08.007"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000321666"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.01963.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0446"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2007000200014"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2004.08.015"},{"key":"e_1_2_5_22_1","first-page":"420","article-title":"Molecular genetic analysis of the interleukin 6 and tumor necrosis factor a gene polymorphisms in multiple myeloma","volume":"37","author":"Iakupova E","year":"2003","journal-title":"Mol Biol (Mosk)"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01714900"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114392"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V85.3.765.bloodjournal853765"}],"container-title":["Asia-Pacific Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajco.12290","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajco.12290","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajco.12290","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T02:45:43Z","timestamp":1696041943000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajco.12290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,31]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1111\/ajco.12290"],"URL":"https:\/\/doi.org\/10.1111\/ajco.12290","archive":["Portico"],"relation":{},"ISSN":["1743-7555","1743-7563"],"issn-type":[{"value":"1743-7555","type":"print"},{"value":"1743-7563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,31]]}}}