{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T08:01:47Z","timestamp":1705478507600},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,3,17]],"date-time":"2016-03-17T00:00:00Z","timestamp":1458172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Tehran University of Medical Sciences","award":["92-01-51-22133"],"award-info":[{"award-number":["92-01-51-22133"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>After the introduction of tyrosine kinase inhibitors for chronic myeloid leukemia (CML), the survival of these patients has increased significantly. However, these new drugs are expensive and impose considerable expense to patients and governments. Epidemiologic and economic evaluation studies provide good information for resource allocation and decision making. We estimated the incidence, prevalence and direct medical cost of CML in Iran.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used the National Cancer Registry (NCR) data from 2006 to 2009 to estimate the incidence rate of CML (ICD\u201010 code C92.1). After adjustment for the underestimation of incidence rates, we used survival rates of CML and estimated the 5\u2010year prevalence for these patients. In addition, we used clinical practice guideline, expert opinions and medical tariffs to estimate the direct medical costs through the prevalence approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After an adjustment for the underestimation, the incidence rate of CML was 0.5 per 100\u2009000 in the I.R. of Iran. The 5\u2010year prevalence was about 2263 cases (2.98 per 100\u2009000). The total direct medical cost of CML was $23\u2009089\u2009323 and the majority of the cost (97%) was related to drug costs. The total cost will increase considerably to $40\u2009728\u2009869 if all patients use the new drug nilotinib (800 mg\/day) as a second\u2010line treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The increased survival of CML patients and a possible increase in incidence of CML in Iran will most likely lead to a considerable rise in its prevalence and economic burden.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.12470","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T02:20:01Z","timestamp":1458354001000},"source":"Crossref","is-referenced-by-count":3,"title":["Estimation of the prevalence and direct medical costs of chronic myeloid leukemia in the I.R. of Iran in the era of tyrosine kinase inhibitors"],"prefix":"10.1111","volume":"13","author":[{"given":"Rajabali","family":"Daroudi","sequence":"first","affiliation":[{"name":"Cancer Research Center Cancer Institute of Iran Tehran University of Medical Sciences (TUMS)  Tehran I.R of Iran"},{"name":"Department of Health Economics and Management School of Public Health  TUMS Tehran I.R of Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehrzad","family":"Mirzania","sequence":"additional","affiliation":[{"name":"Hematology and Medical Oncology Group Cancer Research Center Cancer Institute Imam Khomeini Hospital Complex  TUMS Tehran I.R of Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazila","family":"Nikravanfard","sequence":"additional","affiliation":[{"name":"Cancer Research Center Cancer Institute of Iran Tehran University of Medical Sciences (TUMS)  Tehran I.R of Iran"},{"name":"National Research Ethics Committee Deputy of Research and Technology Ministry of Health and Medical Education  Tehran I.R of Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanambar","family":"Sadighi","sequence":"additional","affiliation":[{"name":"Cancer Research Center Cancer Institute of Iran Tehran University of Medical Sciences (TUMS)  Tehran I.R of Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Sedighi","sequence":"additional","affiliation":[{"name":"Cancer Research Center Cancer Institute of Iran Tehran University of Medical Sciences (TUMS)  Tehran I.R of Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazem","family":"Zendehdel","sequence":"additional","affiliation":[{"name":"Cancer Research Center Cancer Institute of Iran Tehran University of Medical Sciences (TUMS)  Tehran I.R of Iran"},{"name":"Cancer Models Research Center Cancer Institute of Iran  TUMS Tehran I.R of Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-03-490003"},{"key":"e_1_2_6_3_1","volume-title":"Harrison's Principles of Internal Medicine,","author":"Longo D","year":"2012"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199904293401706"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2009.07.007"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2013.01.002"},{"issue":"6","key":"e_1_2_6_7_1","first-page":"378","article-title":"Six\u2010year follow up of imatinib therapy for newly diagnosed chronic myeloid leukemia in Iranian patients","volume":"14","author":"Jalaeikhoo H","year":"2011","journal-title":"Arch Iran Med"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpmed.2013.03.001"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2010.03.033"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-008-0230-0"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2165\/11539190-000000000-00000"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-07-077958"},{"key":"e_1_2_6_13_1","volume-title":"SEER Cancer Statistics Review","author":"Howlader N"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.6.1928"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.13529"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022457"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062867"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-09-047266"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta16230"},{"key":"e_1_2_6_20_1","unstructured":"NegrinRS SchifferCA.Treatment of chronic myeloid leukemia in chronic phase after failure of initial therapy. UpToDate;2015."},{"key":"e_1_2_6_21_1","unstructured":"Iranian cancer registry national report: ministry of health; non\u2010communicable disease management center; cancer office;2006\u20102009."},{"issue":"3","key":"e_1_2_6_22_1","first-page":"2","article-title":"Prevalence and Incidence of premenopausal and postmenopausal breast cancer in Iran in 2010","volume":"5","author":"Rashidian H","year":"2013","journal-title":"Basic & Clinical Cancer Research"},{"key":"e_1_2_6_23_1","unstructured":"Ministry of Health and Medical Education Clinical Practice Guideline For Chronic Myeloid Leukemia Islamic Republic of Iran 2013.(in persian)."},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta16220"},{"key":"e_1_2_6_25_1","article-title":"Clinical Practice Guidelines in Oncology","author":"O'Brien S","year":"2014","journal-title":"Chronic Myelogenous Leukemia, Version 3"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds228"},{"key":"e_1_2_6_27_1","unstructured":"The Central Bank of Islamic Republic of Iran (CBI) Exchange Rate available at:http:\/\/www.Cbi.Ir\/exrates\/rates_fa.Aspx"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.2013.001351"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-12-152"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2014.921299"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt321"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-142-11-200506070-00006"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt323"},{"issue":"2","key":"e_1_2_6_34_1","first-page":"7","article-title":"Audit of a nationwide pathology\u2010based cancer registry in Iran","volume":"3","author":"Zendehdel K","year":"2011","journal-title":"Basic Clin Cancer Res"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-282632"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2010.12.034"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26679"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2008.26.15_suppl.7088"}],"container-title":["Asia-Pacific Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajco.12470","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajco.12470","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajco.12470","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T02:44:20Z","timestamp":1696041860000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajco.12470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,17]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1111\/ajco.12470"],"URL":"https:\/\/doi.org\/10.1111\/ajco.12470","archive":["Portico"],"relation":{},"ISSN":["1743-7555","1743-7563"],"issn-type":[{"value":"1743-7555","type":"print"},{"value":"1743-7563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,17]]}}}