{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T06:10:01Z","timestamp":1718431801638},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,3,21]],"date-time":"2016-03-21T00:00:00Z","timestamp":1458518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study evaluated the survival outcome, pattern of failure and prognostic factors in cervix uteri cancer patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed the data of 60 patients with stages IB\u2010IVA cancer who were treated between January 2004 and December 2010.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Most patients (<jats:italic>n<\/jats:italic>= 50; 83%) had squamous cell carcinoma. Stage IIB was the most common presentation (<jats:italic>n<\/jats:italic>= 41; 68%). Forty\u2010seven patients (78%) received Cisplatin concurrent with radiotherapy (CRT). The 2\u2010 and 4\u2010year overall survival (OS) was 82% and 79%, respectively. Prolongation of the overall treatment time (OAT) for greater than 56 days, advanced stage and pretreatment hemoglobin (Hb) levels (&lt;10 g\/dL) negatively predicted OS (<jats:italic>P<\/jats:italic>= 0.039,<jats:italic>P<\/jats:italic>= 0.044 and<jats:italic>P<\/jats:italic>= 0.008, respectively). The 2\u2010 and 4\u2010year disease\u2010free survival (DFS) rates were 80% and 69%, respectively. Vaginal infiltration and brachytherapy (orthogonal versus CT\u2010based planning) were significant factors for the prediction of relapse (<jats:italic>P<\/jats:italic>= 0.048 and<jats:italic>P<\/jats:italic>= 0.049, respectively). The 2\u2010 and 4\u2010year loco\u2010regional control (LRC) rates were 78% and 70%, respectively, and the distant metastasis\u2010free survival (DMFS) rates were 82% and 79%, respectively. Vaginal infiltration was the only negative predictive factor for LRC (<jats:italic>P<\/jats:italic>= 0.045), and pathological tumor grade was the only factor indicative of distant metastases (<jats:italic>P<\/jats:italic>= 0.037). Grade 3 or 4 late rectal reactions were reported in two patients (3%), and no patients developed grade 3 or 4 urinary reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The treatment results in our cervix uteri cancer patients and the prognostic factors are comparable to those of previous reports. Orthogonal brachytherapy planning and vaginal infiltration negatively predicted relapse.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.12486","type":"journal-article","created":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T08:58:15Z","timestamp":1458637095000},"source":"Crossref","is-referenced-by-count":2,"title":["Outcome of cervix uteri cancer patients: Clinical treatment results and toxicity profile in a retrospective study from Saudi Arabia"],"prefix":"10.1111","volume":"13","author":[{"given":"Mohamed E","family":"El Sayed","sequence":"first","affiliation":[{"name":"Department of Oncology, Radiation Oncology Section King Abdulaziz University Jeddah Saudi Arabia"},{"name":"Radiation Oncology and Nuclear Medicine Department, National Cancer Institute (NCI) Cairo University Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasir A","family":"Bahadur","sequence":"additional","affiliation":[{"name":"Department of Oncology, Radiation Oncology Section King Abdulaziz University Jeddah Saudi Arabia"},{"name":"Radiology Department, King Abdulaziz University Hospital King Abdulaziz University Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashraf H","family":"Hassouna","sequence":"additional","affiliation":[{"name":"Department of Oncology, Radiation Oncology Section King Abdulaziz University Jeddah Saudi Arabia"},{"name":"Radiation Oncology and Nuclear Medicine Department, National Cancer Institute (NCI) Cairo University Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ehab E","family":"Fawzy","sequence":"additional","affiliation":[{"name":"Department of Oncology, Radiation Oncology Section King Abdulaziz University Jeddah Saudi Arabia"},{"name":"Faculty of Medicine Radiation Oncology and Nuclear Medicine Department (NEMROK) Cairo University Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azza M","family":"Nasr","sequence":"additional","affiliation":[{"name":"Radiation Oncology Department, King Abdulaziz Oncology Center King Abdulaziz University Jeddah Saudi Arabia"},{"name":"Radiation Oncology and Nuclear Medicine Department, National Cancer Institute (NCI) Cairo University Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bakr B","family":"Sadiq","sequence":"additional","affiliation":[{"name":"Research Center Department, King Faisal Specialist Hospital and Research Center King Abdulaziz University Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reyad","family":"Dada","sequence":"additional","affiliation":[{"name":"Medical Oncology Section King Abdulaziz University Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid H","family":"Sait","sequence":"additional","affiliation":[{"name":"Gynecology Oncology Unit, Department of Obstetrics and Gynecology Faculty of Medicine King Abdulaziz University Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nisrin M","family":"Anfinan","sequence":"additional","affiliation":[{"name":"Gynecology Oncology Unit, Department of Obstetrics and Gynecology Faculty of Medicine King Abdulaziz University Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,21]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"FerlayJ SoerjomataramI ErvikMet\u00a0al.GLOBOCAN 2012 v1.0 Cancer Incidence and Mortality Worldwide: IARC Cancer Base No. 11 [Internet]. 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