{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T14:08:45Z","timestamp":1790086125726,"version":"4.0.1"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,10,14]],"date-time":"2016-10-14T00:00:00Z","timestamp":1476403200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"},{"start":{"date-parts":[[2016,10,14]],"date-time":"2016-10-14T00:00:00Z","timestamp":1476403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"}],"funder":[{"name":"Xi\\'an Science and Technology Committee, Xi\\'an, Shaanxi Province, China"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asia-Pac J Clin Oncol"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1111\/ajco.12573","type":"journal-article","created":{"date-parts":[[2016,10,14]],"date-time":"2016-10-14T06:44:48Z","timestamp":1476427488000},"page":"44-52","source":"Crossref","is-referenced-by-count":5,"title":["Clinical application of a rapid cervical cancer screening method: Folate receptor-mediated staining of cervical neoplastic epithelia"],"prefix":"10.1111","volume":"13","author":[{"given":"Donghong","family":"LI","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, the Affiliated Guangren Hospital, School of Medicine; Xi'an Jiaotong University; China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology; Shaanxi Province People's Hospital; China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Patholgy, the Affiliated Guangren Hospital, School of Medicine; Xi'an Jiaotong University; China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Yang","sequence":"additional","affiliation":[{"name":"Gaoling County Women and Children's Hospital; China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuping","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, the Affiliated Guangren Hospital, School of Medicine; Xi'an Jiaotong University; China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuige","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology; Shaanxi Province People's Hospital; China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Dong","sequence":"additional","affiliation":[{"name":"GY Highland Biotech LLC; New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,14]]},"reference":[{"key":"10.1111\/ajco.12573-BIB0001|ajco12573-cit-0001","unstructured":"Globocan 2012 http:\/\/globocan.iarc.fr\/Pages\/fact_sheets_cancer.aspx"},{"key":"10.1111\/ajco.12573-BIB0002|ajco12573-cit-0002","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1309\/AJCPTGD94EVRSJCG","article-title":"American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer","volume":"137","author":"Saslow","year":"2012","journal-title":"Am J Clin Pathol"},{"key":"10.1111\/ajco.12573-BIB0003|ajco12573-cit-0003","doi-asserted-by":"crossref","first-page":"E954","DOI":"10.1002\/ijc.27633","article-title":"Accuracy of concurrent visual and cytology screening in detecting cervical cancer precursors in rural India","volume":"131","author":"Deodhar","year":"2012","journal-title":"Int J Cancer"},{"key":"10.1111\/ajco.12573-BIB0004|ajco12573-cit-0004","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ejogrb.2014.03.006","article-title":"CareHPV cervical cancer screening demonstration in a rural population of north India","volume":"176","author":"Labani","year":"2014","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1111\/ajco.12573-BIB0005|ajco12573-cit-0005","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1111\/1471-0528.12646","article-title":"Clinical determinants of a positive visual inspection after treatment with acetic acid for cervical cancer screening","volume":"121","author":"Castle","year":"2014","journal-title":"BJOG"},{"key":"10.1111\/ajco.12573-BIB0006|ajco12573-cit-0006","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1097\/IGC.0000000000000084","article-title":"A multicountry evaluation of care HPV testing, visual inspection with acetic acid, and papanicolaou testing for the detection of cervical cancer","volume":"24","author":"Jeronimo","year":"2014","journal-title":"Int J Gynecol Cancer"},{"key":"10.1111\/ajco.12573-BIB0007|ajco12573-cit-0007","doi-asserted-by":"crossref","first-page":"5667","DOI":"10.7314\/APJCP.2014.15.14.5667","article-title":"Down-regulation of FRalpha inhibits proliferation and promotes apoptosis of cervical cancer cells in vitro","volume":"15","author":"Bai","year":"2014","journal-title":"Asian Pac J Cancer Prev"},{"key":"10.1111\/ajco.12573-BIB0008|ajco12573-cit-0008","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1172\/JCI118192","article-title":"Transduction of folate receptor cDNA into cervical carcinoma cells using recombinant adeno-associated virions delays cell proliferation in vitro and in vivo","volume":"96","author":"Sun","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1111\/ajco.12573-BIB0009|ajco12573-cit-0009","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s10555-014-9539-8","article-title":"Role of the folate receptor in ovarian cancer treatment: evidence, mechanism, and clinical implications","volume":"34","author":"Vergote","year":"2015","journal-title":"Cancer Metastasis Rev"},{"key":"10.1111\/ajco.12573-BIB0010|ajco12573-cit-0010","first-page":"940","article-title":"Modulation of the cytotoxicity of 3'-azido-3'-deoxythymidine and methotrexate after transduction of folate receptor cDNA into human cervical carcinoma: identification of a correlation between folate receptor expression and thymidine kinase activity","volume":"59","author":"Sun","year":"1999","journal-title":"Cancer Res"},{"key":"10.1111\/ajco.12573-BIB0011|ajco12573-cit-0011","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1158\/1055-9965.EPI-09-0493","article-title":"Folate status and aberrant DNA methylation are associated with HPV infection and cervical pathogenesis","volume":"18","author":"Flatley","year":"2009","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1111\/ajco.12573-BIB0012|ajco12573-cit-0012","first-page":"775","article-title":"Expression of folate receptor type alpha in relation to cell type, malignancy, and differentiation in ovary, uterus, and cervix","volume":"8","author":"Wu","year":"1999","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1111\/ajco.12573-BIB0013|ajco12573-cit-0013","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1002\/jps.20457","article-title":"Folate receptor-mediated drug targeting: from therapeutics to diagnostics","volume":"94","author":"Hilgenbrink","year":"2005","journal-title":"J Pharm Sci"},{"key":"10.1111\/ajco.12573-BIB0014|ajco12573-cit-0014","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.addr.2004.01.008","article-title":"Folate-targeted chemotherapy","volume":"56","author":"Leamon","year":"2004","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1111\/ajco.12573-BIB0015|ajco12573-cit-0015","doi-asserted-by":"crossref","first-page":"131","DOI":"10.2174\/1389201053642376","article-title":"Targeting therapeutic and imaging agents to folate receptor positive tumors","volume":"6","author":"Reddy","year":"2005","journal-title":"Curr Pharm Biotechnol"},{"key":"10.1111\/ajco.12573-BIB0016|ajco12573-cit-0016","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s00404-014-3492-1","article-title":"Risk factors for cancer of cervix, status of screening and methods for its detection","volume":"291","author":"Mohanty","year":"2015","journal-title":"Arch Gynecol Obstet"},{"key":"10.1111\/ajco.12573-BIB0017|ajco12573-cit-0017","first-page":"1088","article-title":"Interaction of folate deficiency and aberrant profile of DNA methyltransferase 1 in the progression of cervix carcinogenesis","volume":"46","author":"Wang","year":"2012","journal-title":"Zhonghua Yu Fang Yi Xue Za Zhi"},{"key":"10.1111\/ajco.12573-BIB0018|ajco12573-cit-0018","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11010-012-1362-3","article-title":"Cervical cancer pathogenesis is associated with one-carbon metabolism","volume":"369","author":"Pathak","year":"2012","journal-title":"Mol Cell Biochem"},{"key":"10.1111\/ajco.12573-BIB0019|ajco12573-cit-0019","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1080\/01635581.2014.916318","article-title":"Serum one-carbon metabolites and risk of cervical cancer","volume":"66","author":"Pathak","year":"2014","journal-title":"Nutr Cancer"},{"key":"10.1111\/ajco.12573-BIB0020|ajco12573-cit-0020","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/B978-0-12-380864-6.00004-3","article-title":"Folate and one-carbon metabolism and its impact on aberrant DNA methylation in cancer","volume":"71","author":"Liu","year":"2010","journal-title":"Adv Genet"},{"key":"10.1111\/ajco.12573-BIB0021|ajco12573-cit-0021","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2407-14-803","article-title":"Tumour suppressor gene methylation and cervical cell folate concentration are determinants of high-risk human papillomavirus persistence: a nested case control study","volume":"14","author":"Flatley","year":"2014","journal-title":"BMC Cancer"},{"key":"10.1111\/ajco.12573-BIB0022|ajco12573-cit-0022","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1158\/1078-0432.CCR-14-1101","article-title":"Genomic landscape of human papillomavirus-associated cancers","volume":"21","author":"Rusan","year":"2015","journal-title":"Clin Cancer Res"},{"key":"10.1111\/ajco.12573-BIB0023|ajco12573-cit-0023","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0091905","article-title":"A promising DNA methylation signature for the triage of high-risk human papillomavirus DNA-positive women","volume":"9","author":"Hansel","year":"2014","journal-title":"PLoS One"},{"key":"10.1111\/ajco.12573-BIB0024|ajco12573-cit-0024","doi-asserted-by":"crossref","first-page":"891","DOI":"10.7314\/APJCP.2014.15.2.891","article-title":"PAX1 methylation analysis by MS-HRM is useful in triage of high-grade squamous intraepithelial lesions","volume":"15","author":"Wang","year":"2014","journal-title":"Asian Pac J Cancer Prev"},{"key":"10.1111\/ajco.12573-BIB0025|ajco12573-cit-0025","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1002\/ijc.28723","article-title":"Methylation marker analysis of self-sampled cervico-vaginal lavage specimens to triage high-risk HPV-positive women for colposcopy","volume":"135","author":"Hesselink","year":"2014","journal-title":"Int J Cancer"},{"key":"10.1111\/ajco.12573-BIB0026|ajco12573-cit-0026","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1097\/IGC.0b013e3182158683","article-title":"Human papillomavirus's physical state and cyclin A1 promoter methylation in cervical cancer","volume":"21","author":"Yanatatsaneejit","year":"2011","journal-title":"Int J Gynecol Cancer"},{"key":"10.1111\/ajco.12573-BIB0027|ajco12573-cit-0027","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1349-7006.2008.01001.x","article-title":"Role of iron in carcinogenesis: cancer as a ferrotoxic disease","volume":"100","author":"Toyokuni","year":"2009","journal-title":"Cancer Sci"},{"key":"10.1111\/ajco.12573-BIB0028|ajco12573-cit-0028","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1158\/1055-9965.EPI-12-0073","article-title":"Circulating biomarkers of iron storage and clearance of incident human papillomavirus infection","volume":"21","author":"Siegel","year":"2012","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1111\/ajco.12573-BIB0029|ajco12573-cit-0029","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1001\/jama.287.16.2140","article-title":"New Bethesda terminology and evidence-based management guidelines for cervical cytology findings","volume":"287","author":"Stoler","year":"2002","journal-title":"JAMA"},{"key":"10.1111\/ajco.12573-BIB0030|ajco12573-cit-0030","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1001\/jama.287.16.2120","article-title":"Consensus guidelines for the management of women with cervical cytological abnormalities","volume":"287","author":"Wright","year":"2002","journal-title":"JAMA"},{"key":"10.1111\/ajco.12573-BIB0031|ajco12573-cit-0031","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1111\/j.1525-1438.2006.00651.x","article-title":"The use of electrical impedance spectroscopy in the detection of cervical intraepithelial neoplasia","volume":"16","author":"Abdul","year":"2006","journal-title":"Int J Gynecol Cancer"},{"key":"10.1111\/ajco.12573-BIB0032|ajco12573-cit-0032","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1038\/nm.2472","article-title":"Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-alpha targeting: first in-human results","volume":"17","author":"Dam","year":"2011","journal-title":"Nat Med"},{"key":"10.1111\/ajco.12573-BIB0033|ajco12573-cit-0033","first-page":"2071s","article-title":"Methyl groups in carcinogenesis: effects on DNA methylation and gene expression","volume":"52","author":"Wainfan","year":"1992","journal-title":"Cancer Res"},{"key":"10.1111\/ajco.12573-BIB0034|ajco12573-cit-0034","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1093\/jn\/130.2.129","article-title":"Folate and carcinogenesis: an integrated scheme","volume":"130","author":"Choi","year":"2000","journal-title":"J Nutr"},{"key":"10.1111\/ajco.12573-BIB0035|ajco12573-cit-0035","doi-asserted-by":"crossref","first-page":"9313","DOI":"10.7314\/APJCP.2014.15.21.9313","article-title":"Folate deficiency and FHIT hypermethylation and HPV 16 infection promote cervical cancerization","volume":"15","author":"Bai","year":"2014","journal-title":"Asian Pac J Cancer Prev"},{"key":"10.1111\/ajco.12573-BIB0036|ajco12573-cit-0036","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/1097-4644(20010501)81:2<205::AID-JCB1036>3.0.CO;2-S","article-title":"The rate of folate receptor alpha (FR alpha) synthesis in folate depleted CHL cells is regulated by a translational mechanism sensitive to media folate levels, while stable overexpression of its mRNA is mediated by gene amplification and an increase in transcript half-life","volume":"81","author":"Zhu","year":"2001","journal-title":"J Cell Biochem"},{"key":"10.1111\/ajco.12573-BIB0037|ajco12573-cit-0037","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1016\/j.bbagen.2014.12.016","article-title":"Redox control of viral carcinogenesis: the human papillomavirus paradigm","volume":"1850","author":"Foppoli","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"10.1111\/ajco.12573-BIB0038|ajco12573-cit-0038","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2217\/fvl.10.73","article-title":"HPV-DNA integration and carcinogenesis: putative roles for inflammation and oxidative stress","volume":"6","author":"Williams","year":"2011","journal-title":"Future Virol"},{"key":"10.1111\/ajco.12573-BIB0039|ajco12573-cit-0039","doi-asserted-by":"crossref","first-page":"6751","DOI":"10.1128\/JVI.03355-13","article-title":"Human papillomavirus type 16 E6* induces oxidative stress and DNA damage","volume":"88","author":"Williams","year":"2014","journal-title":"J Virol"},{"key":"10.1111\/ajco.12573-BIB0040|ajco12573-cit-0040","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1002\/cncr.20600","article-title":"Adenocarcinoma in situ of the uterine cervix and disgnostic errors in Papanicolaou smears","volume":"102","author":"Ruba","year":"2004","journal-title":"Cancer"},{"key":"10.1111\/ajco.12573-BIB0041|ajco12573-cit-0041","doi-asserted-by":"crossref","DOI":"10.1007\/s11912-015-0440-6","article-title":"Adenocarcinoma of the cervix: should we treat it differently?","volume":"17","author":"Williams","year":"2015","journal-title":"Curr Oncol Rep"},{"key":"10.1111\/ajco.12573-BIB0042|ajco12573-cit-0042","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.aogh.2014.09.014","article-title":"Screening for cancer in low- and middle-income countries","volume":"80","author":"Sankaranarayanan","year":"2014","journal-title":"Ann Glob Health"},{"key":"10.1111\/ajco.12573-BIB0043|ajco12573-cit-0043","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1097\/IGC.0b013e318256e5e4","article-title":"Accuracy of several cervical screening strategies for early detection of cervical cancer: a meta-analysis","volume":"22","author":"Chen","year":"2012","journal-title":"Int J Gynecol Cancer"},{"key":"10.1111\/ajco.12573-BIB0044|ajco12573-cit-0044","first-page":"619","article-title":"Cervical cancer screening by visual inspection with acetic acid-interobserver variability between nurse and physician","volume":"11","author":"Sherigar","year":"2010","journal-title":"Asian Pac J Cancer Prev"}],"container-title":["Asia-Pacific Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajco.12573","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajco.12573","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/ajco.12573\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T08:40:28Z","timestamp":1625301628000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajco.12573"}},"subtitle":["Folate receptor-mediated cancer screening"],"short-title":[],"issued":{"date-parts":[[2016,10,14]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,2]]}},"URL":"https:\/\/doi.org\/10.1111\/ajco.12573","archive":["Portico"],"relation":{},"ISSN":["1743-7555"],"issn-type":[{"value":"1743-7555","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10,14]]}}}