{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T18:26:37Z","timestamp":1760898397154},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,11,21]],"date-time":"2016-11-21T00:00:00Z","timestamp":1479686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>A nomogram for prediction of 12\u2010year sarcoma\u2010specific survival has been developed based on patients with soft tissue sarcomas treated in Memorial Sloan Kettering Cancer Centre (MSKCC). We aim to evaluate the predictive accuracy of the MSKCC sarcoma nomogram in a cohort of patients treated at an Asian institution. This has not been validated in an Asian population and thus its universal applicability remains unproven.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Between 1990 and 2013, 840 adult patients underwent treatment for primary soft tissue sarcoma (STS) at the National Cancer Centre Singapore. Patients who presented with locally recurrent or metastatic disease were excluded from the analysis. The variables included in the MSKCC nomogram included age at diagnosis, tumor size, histologic grade, histologic subtype, depth and site. A total of 399 patients were left for analysis. The nomogram was validated by assessing its extent of discrimination and level of calibration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients had deep tumors. Disease occurred most commonly in the lower extremity (<jats:italic>n<\/jats:italic> = 149 [37.3%]), the most common histologic subtype was \u201cOthers\u201d (angiosarcoma, ewing's sarcoma, endometrial stromal sarcoma, sarcoma NOS [not otherwise specified] and rhabdomyosarcoma). Sixty\u2010four percent of all patients had high\u2010grade tumors while 36% had low\u2010grade tumors. The median patient age at diagnosis was 54 years (range: 17\u201388 years). The median follow up time for all patients and surviving patients were 29 (range: 1\u2013174) and 33 (range: 1\u2013157) months, respectively. The observed 5\u2010 and 10\u2010year sarcoma\u2010specific survival were 55% and 33%, respectively. The concordance index was 0.71. For level of calibration, the observed correspondence between predicted and actual outcomes suggest that the MSKCC nomogram generally predicts well for patients with higher survival probability, but consistently overpredicts survival for the other groups, in our cohort of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The MSKCC sarcoma nomogram was found to be accurate in terms of extent of discrimination. In terms of level of calibration, it generally predicts well for patients with higher survival probability, but consistently overpredicts survival for the other groups in our population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.12607","type":"journal-article","created":{"date-parts":[[2016,11,21]],"date-time":"2016-11-21T11:46:37Z","timestamp":1479728797000},"source":"Crossref","is-referenced-by-count":6,"title":["Is the Memorial Sloan Kettering Cancer Centre (MSKCC) sarcoma nomogram useful in an Asian population?"],"prefix":"10.1111","volume":"13","author":[{"given":"Deanna Wan Jie","family":"Ng","sequence":"first","affiliation":[{"name":"Division of Surgical Oncology National Cancer Centre Singapore  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace Hwei Ching","family":"Tan","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology National Cancer Centre Singapore  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claramae Shulyn","family":"Chia","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology National Cancer Centre Singapore  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy Xindi","family":"Lim","sequence":"additional","affiliation":[{"name":"Division of Clinical Trials and Epidemiological Sciences National Cancer Centre Singapore  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo Khee","family":"Chee","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology National Cancer Centre Singapore  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard Hong Hui","family":"Quek","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology National Cancer Centre Singapore  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