{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T17:07:43Z","timestamp":1747674463961},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T00:00:00Z","timestamp":1489449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91129720","81100384"],"award-info":[{"award-number":["91129720","81100384"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007162","name":"Guangdong Science and Technology Department","doi-asserted-by":"publisher","award":["2015A050502029","2016A020215123"],"award-info":[{"award-number":["2015A050502029","2016A020215123"]}],"id":[{"id":"10.13039\/501100007162","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The comprehensive genetic alterations underlying the pathogenesis of S\u00e9zary syndrome (SS) remains largely unknown. Previous studies showed that alterations of tumor necrosis factor\u2010\u03b1\u2010induced protein 3 gene (<jats:italic>TNFAIP3<\/jats:italic>; <jats:italic>A20<\/jats:italic>) are frequent in SS. In this study, we characterized the mutation and polymorphisms of <jats:italic>A20<\/jats:italic> in a case with SS and compared with the genetic feature of <jats:italic>A20<\/jats:italic> in T\u2010cell acute lymphoblastic leukemia (T\u2010ALL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using a novel approach based on the combination of fine\u2010tiling array comparative genomic hybridization ( and ligation\u2010mediated polymerase chain reaction (LM\u2010PCR) to identify SS clone, the polymorphisms in the <jats:italic>A20<\/jats:italic> gene (promoter, exons 2\u20139 [coding region] and 3\u2032UTR) were detected by PCR and sequencing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The malignant SS clone was identified as <jats:italic>TCR<\/jats:italic> V\u03b12\u2010J\u03b122 rearrangement without deletion at the <jats:italic>A20<\/jats:italic> loci (6q23\u201027 region) in the SS case. Six polymorphisms were identified, all of them are belonging to single nucleotide polymorphisms (SNPs) that are recorded in genebank: rs5029924, rs5029937, rs2230926, rs582757 and rs77191406, while rs2307859 was not identified in the SS sample, which is found in all T\u2010ALL. The alteration pattern of <jats:italic>A20<\/jats:italic> in this case seemed different from the T\u2010ALL samples, in contrast, it is similar to the alteration of <jats:italic>A20<\/jats:italic> in samples from rheumatoid arthritis or systemic lupus erythematosus with poor clinical outcome and cancer developing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The genetic alteration of <jats:italic>A20<\/jats:italic> in the SS case was different from the T\u2010ALL samples and similar to the cases with refractory autoimmune disease and related to tumorigenesis. The findings lead to discuss whether such SNPs of <jats:italic>A20<\/jats:italic> may link the refractory autoimmune inflammation and the tumorigenesis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.12672","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T20:19:09Z","timestamp":1489522749000},"source":"Crossref","is-referenced-by-count":4,"title":["Different genetic alteration of <i>A20<\/i> in a S\u00e9zary syndrome case with <i>V\u03b12\u2010J\u03b122<\/i> T cell clone"],"prefix":"10.1111","volume":"14","author":[{"given":"Lingling","family":"Zhou","sequence":"first","affiliation":[{"name":"Key Laboratory for Regenerative Medicine of Ministry of Education Jinan University  Guangzhou China"},{"name":"Institute of Hematology, School of Medicine Jinan University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haitao","family":"Zheng","sequence":"additional","affiliation":[{"name":"Institute of Hematology, School of 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