{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T08:16:56Z","timestamp":1695716216702},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,3,29]],"date-time":"2017-03-29T00:00:00Z","timestamp":1490745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To analyze patterns of failure, toxicity, relapse\u2010free survival (RFS), and overall survival (OS) in malignant pleural mesothelioma (MPM) patients treated with intensity\u2010modulated radiation therapy following extrapleural pneumonectomy (EPP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed 18 charts of patients with MPM from 2005 to 2014 who underwent EPP followed by hemithoracic intensity\u2010modulated radiation therapy. Intensity\u2010modulated radiation therapy dose delivery adhered to published lung dose constraints. Kaplan\u2010Meier curves were used to assess the RFS and OS. Median survival times are reported for both RFS and OS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median age was 65 years (range: 40\u201476 years). Chemotherapy was administered in four neo\u2010adjuvant and seven adjuvant patients. Pathological American Joint Committee on Cancer stages II, III, IV, surgical margin, lympho\u2010vascular space, pericardium, and chest wall involvement were seen in 3, 12, 3, 9, 7, 12 and 3 patients, respectively. The majority of the patients received 45 Gy in 25 fractions. The mean lung dose was 7.14 Gy (range: 5 Gy\u20139.3 Gy). The mean V20 was 2.23%. At a median follow\u2010up of 3 years, eight patients were alive (44%); 10 experienced relapse (56%). Median RFS and OS were 24.4 months (95% CI: &gt;16.3 months) and 38.2 months (95% CI: 17.4\u201378.1 months), respectively. Acute toxicities were fatigue, dermatitis, nausea, esophagitis\/dysphagia, cough, and dyspnea on exertion. No grade III, IV, or fatal pulmonary toxicities were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Intensity\u2010modulated radiation therapy following EPP for MPM resulted in RFS and OS comparable to the published literature without significant toxicity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.12680","type":"journal-article","created":{"date-parts":[[2017,3,29]],"date-time":"2017-03-29T05:12:40Z","timestamp":1490764360000},"source":"Crossref","is-referenced-by-count":2,"title":["Intensity modulated radiation therapy after extra\u2010pleural pneumonectomy for malignant pleural mesothelioma is feasible without fatal pulmonary toxicity and provides good survival"],"prefix":"10.1111","volume":"14","author":[{"given":"Sameer","family":"Jhavar","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Baylor Scott and White Health  Temple Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Pruszynski","sequence":"additional","affiliation":[{"name":"Biostatistics Baylor Scott and White Health  Temple Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Gowan","sequence":"additional","affiliation":[{"name":"Hematology and Oncology Baylor Scott and White Health  Temple Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Boyle","sequence":"additional","affiliation":[{"name":"Radiation Oncology Austin Cancer Centers  Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niloyjyoti","family":"Deb","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Baylor Scott and White Health  Temple Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehul","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Baylor Scott and White Health  Temple Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,29]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Malignant Pleural Mesothelioma.NCCN Clinical Practice guidelines in Oncology. 2014.https:\/\/www.nccn.org\/professionals\/physician_gls\/f_guidelines.asp. 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