{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T03:13:22Z","timestamp":1785640402459,"version":"3.56.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,7,3]],"date-time":"2017-07-03T00:00:00Z","timestamp":1499040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Mundipharma Pte Ltd., Singapore"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To examine the treatment practices for cancer pain relief and adverse event management, and the factors related to patient outcomes in the participating countries\/regions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study was a cross\u2010sectional survey conducted between September and December 2013 in 10 countries\/regions across Asia. Adult patients with a history of cancer pain at least 1 month before study entry completed the survey questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>A<\/jats:italic> total of 1190 patients were included. The mean Box Scale\u201011 (BS\u201011) pain score was 6.0 (SD 2.1), with 86.2% experiencing moderate\u2010to\u2010severe pain and 53.2% receiving opioids at time of the survey. The mean BS\u201011 scores were 5.3 (SD 2.1) in the \u201cothers\u201d (single non\u2010opioid medication or untreated) group, 6.3 (SD 2.0) in the \u22652 non\u2010opioids group and 6.7 (SD 1.9) in the opioid group. The proportions of patients experiencing moderate\u2010to\u2010severe pain were 79.1%, 87.3% and 93.7%, respectively. About 70% of patients reported adverse events due to their pain medications, about half had received medications to manage these symptoms. Adverse events were negatively associated with activities of daily living (<jats:italic>P<\/jats:italic> &lt; 0.0001). Pain and hindrance to activities of daily living were negatively associated with employment status (<jats:italic>P<\/jats:italic> = 0.003 and 0.021). Unemployment was significantly associated with poorer quality of life (<jats:italic>P<\/jats:italic> &lt; 0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This analysis demonstrates inadequate management of cancer pain and treatment\u2010related adverse events in the participating cohort. Pain and inadequate management of adverse events were negatively associated with patients\u2019 overall well\u2010being. More collaborative efforts should be taken to optimize pain treatment and increase awareness of adverse event management in physicians.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.12696","type":"journal-article","created":{"date-parts":[[2017,7,3]],"date-time":"2017-07-03T07:58:00Z","timestamp":1499068680000},"page":"159-166","source":"Crossref","is-referenced-by-count":14,"title":["Inadequate treatment practices for pain relief and adverse event management in cancer patients across 10 countries\/regions in Asia: a call for greater efforts to improve standards for patient care"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9466-0242","authenticated-orcid":false,"given":"Kok Yuen","family":"Ho","sequence":"first","affiliation":[{"name":"Pain Management Service Raffles Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Seok","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Minerva","family":"Calimag","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology Clinical Epidemiology and Anesthesiology University of Santo Tomas Faculty of Medicine and Surgery and the UST Hospital  Manila Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ta\u2010Chung","family":"Chao","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, School of Medicine National Yang\u2010Ming University  Taipei Taiwan R.O.C."},{"name":"Division of Medical Oncology Department of Oncology Taipei Veterans General Hospital  Taipei Taiwan R.O.C."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010Chul","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Seoul National University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanlim","family":"Moon","sequence":"additional","affiliation":[{"name":"Mundipharma Pte Ltd.  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