{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T20:49:19Z","timestamp":1765486159304,"version":"3.37.3"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,11,6]],"date-time":"2017-11-06T00:00:00Z","timestamp":1509926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the attitudes of patients with different cancers towards research biopsies outside a clinical trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with metastatic cancer completed a questionnaire that assessed patients\u2019 willingness to consider research biopsies. Research biopsies were divided into two groups: biopsies performed as stand\u2010alone procedures (research purposes only biopsy, RPOB) or performed during a clinically indicated biopsy (additional pass biopsy, APB). Factors analyzed included biopsy timing, biopsy site, sociodemographic information and information about prior trial participation. Univariate and multivariable analyses were conducted using random\u2010effects logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and sixty\u2010five patients with cancer (40 melanoma, 37 colorectal, 32 breast, 30 lung, 26 prostate) completed the questionnaire. Patients with melanoma demonstrated the greatest willingness to consider a research biopsy compared to patients with other cancer types (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Patients\u2019 ethnicity, time since previous biopsies, time since metastatic diagnosis, and previous trial enrolment were all statistically significant for willingness to consider a research biopsy on univariate analysis. When adjusting for statistically significant variables on univariate analysis, the odds of patients considering APBs were 14.6 times greater than RPOBs (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). Patients were also more willing to consider having blood or skin taken for research purposes (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001<jats:italic>)<\/jats:italic> compared to liver and bone biopsies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with cancer show a greater willingness to consider APBs compared to RPOBs, and biopsies performed at less invasive body sites. There are differences in the attitudes of patients with different cancers towards research biopsies. Further research addressing motivations and barriers to research biopsies should be considered to increase the availability of this important resource.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.12783","type":"journal-article","created":{"date-parts":[[2017,11,6]],"date-time":"2017-11-06T05:52:35Z","timestamp":1509947555000},"page":"231-238","source":"Crossref","is-referenced-by-count":2,"title":["Attitudes of patients with metastatic cancer towards research biopsies"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0384-704X","authenticated-orcid":false,"given":"Danielle H.","family":"Robinson","sequence":"first","affiliation":[{"name":"Austin Health  Heidelberg Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonid","family":"Churilov","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health  VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy U.","family":"Lin","sequence":"additional","affiliation":[{"name":"Dana\u2010Farber Cancer Institute  Boston MA USA"},{"name":"Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elgene","family":"Lim","sequence":"additional","affiliation":[{"name":"Garvan Institute of Medical Research  Darlinghurst NSW Australia"},{"name":"University of New South Wales  Kensington NSW Australia"},{"name":"St Vincent's Health  Darlinghurst NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davinia","family":"Seah","sequence":"additional","affiliation":[{"name":"University of New South Wales  Kensington NSW Australia"},{"name":"St Vincent's Health  Darlinghurst NSW Australia"},{"name":"University of Notre Dame Australia  Darlinghurst NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1677\/ERC-10-0136"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.27.2443"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.05.7125"},{"key":"e_1_2_7_5_1","unstructured":"Welfare AIoHa.Cancer in Australia: an overview 2014. Canberra Australia;2014."},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.4496"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2011-0043"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000368161"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2011.114"},{"key":"e_1_2_7_10_1","first-page":"1","article-title":"Research biopsies in phase I studies: views and perspectives of participants and investigators","volume":"34","author":"Pentz RD","year":"2012","journal-title":"Irb: a Review of Human Subjects Res"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.44.8589"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.4081\/oncol.2013.e5"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1740774512464438"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28966"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt067"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2013.03.011"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clcc.2016.09.008"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-013-2717-5"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/jme.2006.016006"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/1049732310373753"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu480"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0136407"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/gm474"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1416-5"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2015-0112"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-013-1404-6"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.9896"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.43.1718"},{"key":"e_1_2_7_29_1","first-page":"9","article-title":"Consent for nondiagnostic research biopsies: a pilot study of participant recall and therapeutic orientation","volume":"36","author":"Abadie R","year":"2014","journal-title":"IRB: Ethics and Human Research"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27397"}],"container-title":["Asia-Pacific Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajco.12783","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajco.12783","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T15:36:38Z","timestamp":1695483398000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajco.12783"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,6]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1111\/ajco.12783"],"URL":"https:\/\/doi.org\/10.1111\/ajco.12783","archive":["Portico"],"relation":{},"ISSN":["1743-7555","1743-7563"],"issn-type":[{"type":"print","value":"1743-7555"},{"type":"electronic","value":"1743-7563"}],"subject":[],"published":{"date-parts":[[2017,11,6]]}}}