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Exosomal tetraspanin proteins like CD63, CD9 and CD81 play a critical role in sorting, selective recruitment of biomolecules, target selection, cell\u2010specific entry, capturing, angiogenesis and vasculogenesis. These tetraspanins are being used as markers for oral, colorectal and colon cancers and glioblastoma. However, exosomal markers with robust specificity for early detection of carcinomas are the furthest along. EXO CARTA database shows the presence of CD151 in exosomes of colorectal, melanoma, ovarian and prostate cancers. CD151 preferentially targets exosomes to lung, lymph node and stroma cells. The present review discussed the possible role of tetraspanins in the formation, cargo selection, target selection and uptake of exosomes and suggests exciting new directions for future research.<\/jats:p>","DOI":"10.1111\/ajco.12869","type":"journal-article","created":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T18:04:27Z","timestamp":1522001067000},"page":"383-391","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":97,"title":["Exosomal tetraspanins as regulators of cancer progression and metastasis and novel diagnostic markers"],"prefix":"10.1111","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2448-1681","authenticated-orcid":false,"given":"Rama Rao","family":"Malla","sequence":"first","affiliation":[{"name":"Department of Biochemistry Cancer Biology Lab Institute of Science Gandhi Institute of Technology and Management (GITAM) (Deemed to be university)  Visakhapatnam 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