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The purpose of this study was to analyze the miRNA expression pattern that may be related to <jats:italic>BCL11B<\/jats:italic> regulation in T\u2010ALL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Quantitative real\u2010time PCR was used to detect the miRNAs miR\u201017\u20103p, miR\u201017\u20105p, miR\u201029c\u20103p, miR\u201092a\u20103p, miR\u2010214\u20103p and miR\u2010214\u20105p, the <jats:italic>BCL11B<\/jats:italic> expression level in peripheral blood mononuclear cells which was obtained from 17 de novo and untreated T\u2010ALL patients, and 15 healthy individuals (HIs) served as control. Correlations between the relative miRNA expression levels and <jats:italic>BCL11B<\/jats:italic> were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Based on the computational prediction that certain miRNAs bind the <jats:italic>BCL11B<\/jats:italic> 3\u2032\u2010UTR, miR\u201017\u20103p, miR\u201017\u20105p, miR\u201029c\u20103p, miR\u201092a\u20103p, miR\u2010214\u20103p and miR\u2010214\u20105p were found to be candidates for regulating <jats:italic>BCL11B<\/jats:italic>. The expression levels of the six miRNAs were decreased compared with HIs, and with the exception of miR\u201017\u20105p, statistically significant differences in expression levels were found in the T\u2010ALL group. Moreover, while significantly higher <jats:italic>BCL11B<\/jats:italic> expression was found in the T\u2010ALL group, a negative trend in the correlation level for all six miRNAs could be found in all groups; however, statistical significance was only found for miR\u2010214\u20103p in the T\u2010ALL group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>miRNA downregulation together with <jats:italic>BCL11B<\/jats:italic> upregulation suggests that miR\u201017, miR\u201029c, miR\u201092a and miR\u2010214 might be involved in <jats:italic>BCL11B<\/jats:italic> regulation. The therapeutic promise of regulating the expression of these miRNAs for T\u2010ALL therapy may be considered in the future.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.12979","type":"journal-article","created":{"date-parts":[[2018,5,11]],"date-time":"2018-05-11T08:02:03Z","timestamp":1526025723000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Downregulated miR\u201017, miR\u201029c, miR\u201092a and miR\u2010214 may be related to <i>BCL11B<\/i> overexpression in T\u00a0cell acute lymphoblastic leukemia"],"prefix":"10.1111","volume":"14","author":[{"given":"Zifan","family":"He","sequence":"first","affiliation":[{"name":"Key Laboratory for Regenerative Medicine of Ministry of Education Institute of Hematology School of Medicine Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwei","family":"Liao","sequence":"additional","affiliation":[{"name":"Key Laboratory 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