{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T09:28:53Z","timestamp":1760866133646,"version":"3.37.3"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,5,21]],"date-time":"2018-05-21T00:00:00Z","timestamp":1526860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005795","name":"Chang Gung Memorial Hospital, Linkou","doi-asserted-by":"publisher","award":["CLRPG3C0012","CMRPG1B0571","CORPG3G0981"],"award-info":[{"award-number":["CLRPG3C0012","CMRPG1B0571","CORPG3G0981"]}],"id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST103\u20102325\u2010B\u2010182\u2010005"],"award-info":[{"award-number":["MOST103\u20102325\u2010B\u2010182\u2010005"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>A sustained proportion of advanced hepatocellular carcinoma (HCC) patients worldwide received either chemotherapy or sorafenib. However, to date, effective and convenient biomarkers to predict their therapeutic outcomes remained elusive. Hypothyroidism was associated with favorable anticancer treatment outcomes in several advanced cancers. Here, we aimed to investigate the potential of using thyroid\u2010stimulating hormone (TSH) and free T4 (FT4) levels as biomarkers to predict clinical outcomes in HCC patients receiving chemotherapy or sorafenib.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Total 123 advanced HCC patients at Barcelona Clinical Liver Cancer Stage C were included. They were separated into two cohorts, one treated by sorafenib (<jats:italic>n<\/jats:italic>\u00a0=\u00a062) and the other by chemotherapy (<jats:italic>n<\/jats:italic>\u00a0=\u00a061). Clinical data including TSH and FT4 were retrieved and correlated with treatment outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Because of restriction in local insurance policy, the baseline liver function reserve was better in patients receiving sorafenib. Therefore, the two cohorts were analyzed separately. The results showed that a higher (&gt;\u00a0median) TSH \u00d7 FT4 value was independently associated with favorable time\u2010to\u2010tumor progression (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.006) and overall survival (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002) if chemotherapy was provided; whereas it was associated with unfavorable time\u2010to\u2010tumor progression (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.017) and overall survival (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001) if sorafenib was administrated. These opposite associations remained valid when patients with Child\u2013Pugh class A liver function from either cohort were included for analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A novel thyroid function index, TSH \u00d7 FT4, significantly predicted opposite clinical outcomes in advanced HCC patients receiving sorafenib or chemotherapy treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.12983","type":"journal-article","created":{"date-parts":[[2018,5,22]],"date-time":"2018-05-22T01:20:20Z","timestamp":1526952020000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A novel thyroid function index associated with opposite therapeutic outcomes in advanced hepatocellular carcinoma patients receiving chemotherapy or sorafenib"],"prefix":"10.1111","volume":"14","author":[{"given":"Yu\u2010De","family":"Chu","sequence":"first","affiliation":[{"name":"Liver Research Center Chang Gung Memorial Hospital  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwang\u2010Huei","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Medicine Chang\u2010Gung University  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya\u2010Hui","family":"Huang","sequence":"additional","affiliation":[{"name":"Liver Research Center Chang Gung Memorial Hospital  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen\u2010Chun","family":"Lin","sequence":"additional","affiliation":[{"name":"Liver Research Center Chang Gung Memorial Hospital  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien\u2010Fu","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Diagnosis Radiology Chang Gung Memorial Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ta\u2010Sen","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of General Surgery Chang Gung Memorial Hospital  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Chen","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of General Surgery Chang Gung Memorial Hospital  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7376-275X","authenticated-orcid":false,"given":"Chau\u2010Ting","family":"Yeh","sequence":"additional","affiliation":[{"name":"Liver Research Center Chang Gung Memorial Hospital  Taoyuan Taiwan"},{"name":"Molecular Medicine Research Center Chang Gung University  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29210"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2014.08.007"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i47.18059"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000343828"},{"key":"e_1_2_11_6_1","first-page":"6877","article-title":"Transcatheter arterial embolic therapies for hepatocellular carcinoma: a literature review","volume":"34","author":"Nishikawa H","year":"2014","journal-title":"Anticancer Res"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-11-117"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.3.1097"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2007.12.008"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910500625"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.01.041"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0b013e32835c7a47"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-010-0627-2"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.132.10.1041"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22793"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.07.011"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24740"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21959"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2013.5"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1247132"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037188"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2300"},{"key":"e_1_2_11_23_1","first-page":"2","article-title":"Freedom of expression beyond the thyroid: the thyroid\u2010stimulating hormone receptor in the adipocyte","volume":"2","author":"Sorisky A","year":"2014","journal-title":"OA Biochem"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2005.256"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0708857"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70285-7"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000449343"}],"container-title":["Asia-Pacific Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajco.12983","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajco.12983","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T23:24:40Z","timestamp":1694993080000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajco.12983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,21]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1111\/ajco.12983"],"URL":"https:\/\/doi.org\/10.1111\/ajco.12983","archive":["Portico"],"relation":{},"ISSN":["1743-7555","1743-7563"],"issn-type":[{"type":"print","value":"1743-7555"},{"type":"electronic","value":"1743-7563"}],"subject":[],"published":{"date-parts":[[2018,5,21]]},"assertion":[{"value":"2017-10-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}