{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:35:54Z","timestamp":1747182954923,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,12,9]],"date-time":"2018-12-09T00:00:00Z","timestamp":1544313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Mitomycin C (MMC) plus standard 5\u2010fluorouracil (FU) infusion in weeks 1 and 5 often contributes to radiotherapy interruptions and possibly less\u2010than\u2010ideal outcomes in anal cancer. This study was to evaluate alternative strategies for chemotherapy delivery that might be less toxic or more efficacious, and outcomes of patient\u2010initiated treatment interruption for severe acute toxicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>This was a prospective, nonrandomized study for patients with T1\u20104N0\u20103M0 anal squamous carcinoma. Radiotherapy of 54\u00a0Gy in 30 fractions over 6 weeks was given with infusion FU 300\u00a0mg\/m<jats:sup>2<\/jats:sup>\/day for 96\u00a0hours\/week for 6 weeks plus bolus MMC at 10\u00a0mg\/m<jats:sup>2<\/jats:sup> on D1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty patients were recruited (72% female). Median age was 60.5 years (35\u201384). Forty\u2010seven patients (94%) received 54\u00a0Gy. Median duration of chemoradiation was 39 days (37\u2013105). Grade 3 and 4 acute toxicity were observed in 66%. Thirty\u2010one percent with severe acute toxicity developed severe late toxicity. Of those who experienced severe late skin toxicity, 29% did not have severe acute toxicity.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>Disease\u2010free survival at 5 years was 74% (95% confidence interval [CI], 60\u201384), and at 9 years 61% (95% CI, 46\u201374). Overall survival at 5 years was 84% (95% CI, 71\u201392), and at 9 years 67% (95% CI, 50\u201381). Colostomy\u2010free survival at 5 years was 70% (95% CI, 56\u201381), and at 9 years 57% (95% CI, 40\u201372).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>It is feasible to deliver chemoradiation with bolus MMC and protracted infusion FU for anal cancer. Efficacy and toxicity of this regimen seem similar to conventional chemoradiation with FU\/MMC. Acute skin toxicity is not a reliable predictor of severe late skin toxicity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.13106","type":"journal-article","created":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T01:44:43Z","timestamp":1544406283000},"page":"75-81","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A clinical trial with protracted infusion 5\u2010fluorouracil and mitomycin C for localized squamous cell carcinoma of the anus"],"prefix":"10.1111","volume":"15","author":[{"given":"David","family":"Ngan","sequence":"first","affiliation":[{"name":"Royal Adelaide Hospital Central Adelaide Local Health Network  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Peter MacCallum Cancer Centre  Melbourne Victoria 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