{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:35:55Z","timestamp":1747182955121,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T00:00:00Z","timestamp":1550016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Omission of axillary lymph node dissection (ALND) after positive sentinel lymph biopsy (SLNB) has become a standard procedure for breast cancer patients with one or two metastatic lymph nodes. Here the aim was model development for selection for ALND.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>We analyzed 323 positive SLNB breast cancer patients, who afterwards underwent ALND. In 126 (39%), there were positive additional axillary lymph nodes. Specimens of resected lymph nodes were scanned and the volumes of tumors (expressed as diameter in mm) were calculated. The maximal diameter of metastasis in the sentinel lymph nodes (SLN<jats:sub>Dmax<\/jats:sub>) and axillary lymph nodes (ALN<jats:sub>Dsum<\/jats:sub>) indicated tumor load in the resected lymph nodes. ALN<jats:sub>Dsum<\/jats:sub> higher or equal to 5\u00a0mm was defined as high and present in 62 patients (21%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Risk factors for high ALN<jats:sub>Dsum<\/jats:sub> were primary tumor diameter (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0092), histopathological type (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0173), number of positive SLNs (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0012), type of metastasis (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0025), molecular type (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0037), SLN<jats:sub>Dmax<\/jats:sub> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0001), and Her\u20102 status (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0093). Independent variables for high ALN<jats:sub>Dsum<\/jats:sub> were SLN<jats:sub>Dmax<\/jats:sub> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001), number of positive SLNs (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0237) and primary tumor diameter (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0296).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Twenty\u2010one percent patients with positive SLNB are at risk of high ALN<jats:sub>Dsum<\/jats:sub>. SLN<jats:sub>Dmax<\/jats:sub> is the strong predictive factor for high ALN<jats:sub>Dsum<\/jats:sub> after positive ALND.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.13113","type":"journal-article","created":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T04:53:16Z","timestamp":1550119996000},"page":"121-127","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The diameter of metastasis in positive sentinel lymph node biopsy affects axillary tumor load in early breast cancer"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7519-4389","authenticated-orcid":false,"given":"Micha\u0142","family":"Falco","sequence":"first","affiliation":[{"name":"Radiation Oncology Department West Pomeranian Oncology Center  Szczecin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart\u0142omiej","family":"Masoj\u0107","sequence":"additional","affiliation":[{"name":"Radiation 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