{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T22:48:21Z","timestamp":1772664501402,"version":"3.50.1"},"reference-count":68,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T00:00:00Z","timestamp":1551830400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"AstraZeneca Limited"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p><jats:italic>BRCA<\/jats:italic> mutation (BRCAmut) testing is an important tool for the risk assessment, prevention and early diagnosis of breast cancer (BC) and ovarian cancer (OC), and more recently, for determining patient susceptibility to targeted therapy. This study assessed the current BRCAmut testing patterns and explored physicians\u2019 perspectives on the utilities and optimal sequencing of the testing, in order to facilitate and standardize testing practices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical specialists in BC and OC in Hong Kong were invited to complete a questionnaire on BRCAmut testing practices. A panel of specialists with extensive BRCAmut testing experience was also convened to develop consensus statements on testing, using the Delphi method and an anonymous electronic voting system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The survey respondents (<jats:italic>n<\/jats:italic>\u00a0=\u00a071) recognized family history (FH) of BC and\/or OC and an early age of onset as key factors for referring BRCAmut testing. The proportion of respondents who would test all OCs regardless of FH or age, as per the recent international guideline, was low (28.2%). The largest hurdles to testing were the <jats:italic>cost<\/jats:italic>, as well as <jats:italic>the availability of next\u2010generation sequencing\u2010accredited testing and genetic counseling facilities<\/jats:italic>. The panelists suggested that the sequence of somatic testing followed by germline testing may help address both the imminent need of treatment planning and longer term hereditary implications. The potential emotional and financial burdens of BRCAmut testing should be weighed against the potential therapeutic benefits, and the type and timing of testing personalized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Accessibility of BRCAmut testing to all at\u2010risk individuals will be achievable through improvements in testing affordability, as well as widened availability of accredited testing and genetic counseling facilities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.13116","type":"journal-article","created":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T08:19:45Z","timestamp":1551860385000},"page":"20-31","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<i>BRCA<\/i> mutation testing for ovarian cancer in the context of available targeted therapy: Survey and consensus of Hong Kong specialists"],"prefix":"10.1111","volume":"15","author":[{"given":"Ava","family":"Kwong","sequence":"first","affiliation":[{"name":"Department of Surgery The University of Hong Kong  Hong Kong"},{"name":"Department of Medicine The University of Hong Kong  Hong Kong"},{"name":"Cancer Genetics Center Hong Kong Sanatorium and Hospital  Hong Kong"},{"name":"Hong Kong Hereditary Breast Cancer Family Registry  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ka\u2010Leung Danny","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Surgery The University of Hong Kong  Hong Kong"},{"name":"Department of Medicine The University of Hong Kong  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chan\u2010Chee Victor","family":"Hsue","sequence":"additional","affiliation":[{"name":"Clinical Oncologist Private Practice  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sze\u2010Ki","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Princess Margaret Hospital  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching\u2010Yu Roland","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Medicine The University of Hong Kong  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwong\u2010Chuen Angus","family":"Leung","sequence":"additional","affiliation":[{"name":"Clinical Oncologist Private Practice  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai\u2010Cheong Roger","family":"Ngan","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Gleneagles Hospital  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Inda","family":"Soong","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Pamela Youde Nethersole Eastern Hospital  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,6]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2644"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-2243"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2013.5"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-15-0714"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu172"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10166"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-015-3306-6"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.20"},{"issue":"1","key":"e_1_2_13_10_1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.18632\/oncotarget.12306","article-title":"Prognostic significance of BRCA mutations in ovarian cancer: an updated systematic review with meta\u2010analysis","volume":"8","author":"Xu K","year":"2016","journal-title":"Oncotarget"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-1465"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12905-014-0150-5"},{"key":"e_1_2_13_13_1","unstructured":"U.S. Foodand Drug Administration.Drugs@FDA: FDA Approval Drug Products. Available at:https:\/\/www.accessdata.fda.gov\/scripts\/cder\/daf\/index.cfm?event=overview.process&applno=206162. Accessed May 23 2018."},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70228-1"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30376-X"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.50.9257"},{"key":"e_1_2_13_17_1","unstructured":"The Society of Gynecologic Oncology.SGO Clinical Practice Statement: Genetic Testing for Ovarian Cancer.2014. Available at:http:\/\/www.sgo.org\/clinical-practice\/guidelines\/genetic-testing-for-ovarian-cancer\/. Accessed May 21 2018."},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt333"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw360"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw327"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21536"},{"key":"e_1_2_13_22_1","unstructured":"National Collaborating Centre for Cancer (UK).Familial Breast Cancer: Classification and Care of People at Risk of Familial Breast Cancer and Management of Breast Cancer and Related Risks in People with a Family History of Breast Cancer. Cardiff UK: National Collaborating Centre for Cancer;2013."},{"key":"e_1_2_13_23_1","unstructured":"National Institute for Health and Care Excellence.Familial Breast Cancer: Classification Care and Managing Breast Cancer and Related Risks in People with a Family History of Breast Cancer.2013. Available at:http:\/\/nice.org.uk\/guidance\/cg164. Accessed May 21 2018."},{"key":"e_1_2_13_24_1","unstructured":"National Institute for Health and Care Excellence.Olaparib for Maintenance Treatment of Relapsed Platinum\u2010Sensitive BRCA Mutation\u2010Positive Ovarian Fallopian Tube and Peritoneal Cancer after Response to Second\u2010Line or Subsequent Platinum\u2010Based Chemotherapy.2016. Available at:http:\/\/nice.org.uk\/guidance\/ta381. Accessed May 21 2018."},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr373"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897-012-9547-1"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.435"},{"key":"e_1_2_13_28_1","unstructured":"National Comprehensive Cancer Network.Genetic\/Familial High\u2010Risk Assessment: Breast and Ovarian: Version 1.2018 \u2014 October 3 2017. Available at:https:\/\/www.nccn.org\/professionals\/physician_gls\/default.aspx. Accessed May 22 2018."},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002296"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.12.015"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2016.03.009"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2009.02.001"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.39.8545"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2015.11.001"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2015.10.010"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2354.2008.01065.x"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26166"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897-017-0135-2"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1089\/gtmb.2012.0381"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-016-9921-5"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897-013-9598-y"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2017.01.027"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-12-1280"},{"key":"e_1_2_13_44_1","unstructured":"Hong Kong Cancer Registry Hospital Authority.Ovarian Cancer in 2016. Available at:https:\/\/www3.ha.org.hk\/cancereg\/pdf\/factsheet\/2016\/ovary_2016.pdf. Accessed May 22 2018."},{"key":"e_1_2_13_45_1","unstructured":"Hong Kong Hereditary Breast Cancer Family Registry.Our Statistics. Available at:http:\/\/www.asiabreastregistry.com\/en\/hereditary-cancers\/our-statistics. Accessed May 23 2018."},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043994"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-011-1406-y"},{"key":"e_1_2_13_48_1","unstructured":"Hong Kong Academy of Medicine.Responses to BRCA Gene Mutation & Related Medical Issues. Available at:https:\/\/www.hkam.org.hk\/hkamweb\/pages_1_202.html. Accessed May 22 2018."},{"key":"e_1_2_13_49_1","unstructured":"Centre for Health Protection.2016 Recommendations of Cancer Expert Working Group on Cancer Prevention and Screening\u2014An Overview for Health Professionals. Available at:https:\/\/www.chp.gov.hk\/files\/pdf\/overview_of_cewg_recommendations_professional_hp.pdf. Accessed May 23 2018."},{"key":"e_1_2_13_50_1","volume-title":"The Delphi Method: Techniques and Applications","author":"Linstone HA","year":"2002"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2017.06.002"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e318159a318"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2009.07.003"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2017.03.108"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2016.11.021"},{"key":"e_1_2_13_56_1","first-page":"171","article-title":"A new paradigm of genetic testing for hereditary breast\/ovarian cancers","volume":"22","author":"Kwong A","year":"2016","journal-title":"Hong Kong Med J"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-014-0121-3"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2015.173"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2015.30"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2016.10.002"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897-011-9351-3"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2015.396"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2014.75"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2015.3048"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2017.05.037"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep29506"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2017.01.030"},{"issue":"2","key":"e_1_2_13_68_1","first-page":"143","article-title":"More breast cancer patients prefer BRCA\u2010mutation testing without prior face\u2010to\u2010face genetic counseling","volume":"13","author":"Sie A","year":"2014","journal-title":"Fam Cancer"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2016.10.006"}],"container-title":["Asia-Pacific Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajco.13116","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajco.13116","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajco.13116","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajco.13116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T22:32:32Z","timestamp":1694385152000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajco.13116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":68,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1111\/ajco.13116"],"URL":"https:\/\/doi.org\/10.1111\/ajco.13116","archive":["Portico"],"relation":{},"ISSN":["1743-7555","1743-7563"],"issn-type":[{"value":"1743-7555","type":"print"},{"value":"1743-7563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"2019-03-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}