{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:43:28Z","timestamp":1787013808170,"version":"build-2736575974"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T00:00:00Z","timestamp":1551225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We report on the unique case of a patient with antisynthetase syndrome and metastatic non\u2013small cell lung cancer undergoing therapy with the PD\u20101 checkpoint inhibitor, nivolumab. Despite adequate autoimmune disease control over a period of 12 months, the patient rapidly experienced a flare of interstitial lung disease following initial nivolumab administration, which ultimately proved fatal. The use of immune checkpoint inhibitors in patients with autoimmune disease is becoming more commonplace, however this is the first reported case of the use of these agents in a patient with antisynthetase syndrome. Additionally, the patient's initial clinical presentation with antisynthetase syndrome and simultaneous primary lung cancer, a rare association of which there are few case reports, makes this case interesting and unusual.<\/jats:p>","DOI":"10.1111\/ajco.13141","type":"journal-article","created":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T22:37:13Z","timestamp":1551307033000},"page":"266-269","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Immune checkpoint inhibitor use in antisynthetase syndrome"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7313-7823","authenticated-orcid":false,"given":"David","family":"Mackintosh","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Gold Coast University Hospital  Southport QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed F.","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Gold Coast University Hospital  Southport QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Gold Coast University Hospital  Southport QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Basham","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Gold Coast University Hospital  Southport QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,27]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.12759"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.7326\/M17-2073"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2017.12.008"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/CPM.0000000000000171"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-015-8511-x"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.1703519"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw443"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.77.0305"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21387"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30513"}],"container-title":["Asia-Pacific Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajco.13141","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajco.13141","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T23:00:26Z","timestamp":1694300426000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajco.13141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,27]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1111\/ajco.13141"],"URL":"https:\/\/doi.org\/10.1111\/ajco.13141","archive":["Portico"],"relation":{},"ISSN":["1743-7555","1743-7563"],"issn-type":[{"value":"1743-7555","type":"print"},{"value":"1743-7563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,27]]},"assertion":[{"value":"2018-10-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}