{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T17:11:33Z","timestamp":1776273093886,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T00:00:00Z","timestamp":1558310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Adenoid cystic carcinoma (ACC) of the trachea and bronchus is rare, representing 1% of all respiratory tract cancers. We presented our experiences in treating tracheal\u2013bronchial ACC and the results of long\u2010term surveillance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective study of treating tracheo\u2013bronchial ACC. From 2009 to 2014, 42 patients presented to our department. All of them received surgical resection and\u00a0adjunctive therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>R0 resections were achieved in 33 patients, whereas 15 patients whose lesions spread outside the tracheo\u2013bronchial lumens. Nine patients had R1 resections followed by radiation and chemotherapy. The 5 year survival rate of R1 resection group showed no difference compared to the R0 resection group, but the 5 year disease\u2010free survival rate showed difference in extra\u2010lumenal invasion (ELI) and non\u2010ELI group (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.0357\u00a0&lt;\u00a00.05), although no difference was seen in the overall survival rate in these two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ACC of the trachea and bronchus is a rare and low\u2010to\u2010moderate grade\u00a0malignant tumor. When the R0 resection is over risky or may cause mortal complication, the R1 resection with adjunctive therapy is acceptable for patients to obtain a promising prognosis, whereas pathological ELI is an adverse prognostic indicator.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.13162","type":"journal-article","created":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T02:03:10Z","timestamp":1558404190000},"page":"244-249","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Tracheo\u2013bronchial adenoid cystic carcinoma: A retrospective study"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8222-5761","authenticated-orcid":false,"given":"Ye","family":"Ning","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Shanghai Pulmonary Hospital Tongji University School of Medicine  Shanghai 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