{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:21:10Z","timestamp":1762431670025,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T00:00:00Z","timestamp":1563408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Intensity\u2010modulated radiotherapy (IMRT) has demonstrated improved local control in extremity soft tissue sarcoma (STS) after limb\u2010sparing surgery compared with three\u2010dimensional conformal radiation therapy. Our purpose was to evaluate sliding\u2010window IMRT (SW\u2010IMRT) and volumetric arc therapy (VMAT) in planning target volume (PTV) coverage and dose to organs\u2010at\u2010risk (OAR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixteen patients undergoing postoperative RT for lower extremity STS were included. For each patient, one VMAT plan and one SW\u2010IMRT plan were proposed. Both were evaluated using cumulative dose\u2013volume histogram data for OAR and PTVs. Prescribed dose was 66\u00a0Gy (2\u00a0Gy\/fraction) to PTV1 and 56\u00a0Gy (1.69\u00a0Gy\/fraction) to PTV2. OARs contoured were femur, neurovascular bundle, minimum tissue corridor, normal tissue outside PTV2, joint and genitalia. <jats:italic>T<\/jats:italic>\u2010Student test was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eleven male (69%) and five female patients (31%) were analyzed. Mean age was 60 years. Both techniques showed optimal target coverage, conformity index (CI) and homogeneity index (HI). VMAT PTV2 CI was 1.13 (mean)\u00a0\u00b1\u00a00.08 (standard deviation) versus 1.19\u00a0\u00b1\u00a00.10 SW\u2010IMRT PTV2 CI (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). VMAT PTV1 HI was 0.09\u00a0\u00b1\u00a00.01 versus 0.08\u00a0\u00b1\u00a00.01 SW\u2010IMRT PTV1 HI (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Regarding OARs, VMAT delivered lower dose to femur, genitalia, normal tissue outside PTV2 and joints. SW\u2010IMRT spared tissue corridor mean dose (10.4\u00a0Gy\u00a0\u00b1\u00a06.8\u00a0Gy) versus (14.7\u00a0\u00b1\u00a06.5\u00a0Gy) VMAT (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both techniques achieved great conformity, homogeneity and coverage of PTV. VMAT produced lower dose to OARS and SW\u2010IMRT was superior in sparing dose to normal\u2010tissue\u2010corridor, which could reduce risk of lymphedema.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.13220","type":"journal-article","created":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T04:58:58Z","timestamp":1563512338000},"page":"371-376","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dosimetric comparison of volumetric\u2010arc therapy versus sliding window intensity\u2010modulated radiotherapy in postoperative treatment for primary soft tissue sarcoma of the thigh"],"prefix":"10.1111","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3009-3626","authenticated-orcid":false,"given":"Irene","family":"Ortiz Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Radiation Oncology Department Hospital Universitari Son Espases  Palma de Mallorca 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Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meritxell","family":"Vidal Borr\u00e1s","sequence":"additional","affiliation":[{"name":"Radiation Oncology Department Hospital Universitari Son Espases  Palma de Mallorca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neus","family":"Aymar Sal\u00eds","sequence":"additional","affiliation":[{"name":"Radiation Oncology Department Hospital Universitari Son Espases  Palma de Mallorca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon","family":"Gadea Quinteiro","sequence":"additional","affiliation":[{"name":"Radiation Oncology Department Hospital Universitari Son Espases  Palma de Mallorca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1170-1702","authenticated-orcid":false,"given":"Esther","family":"Jim\u00e9nez Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Radiation Oncology Department Complejo 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