{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T18:42:03Z","timestamp":1780512123411,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T00:00:00Z","timestamp":1566950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>The Z0011 randomized trial demonstrated no significant difference in axillary recurrence rate or survival with or without axillary dissection in patients with a positive sentinel node biopsy. However, there is continuing controversy regarding the generalizability of its results, and axillary dissection provides additional pathologic staging information that may guide adjuvant therapy. Thus, axillary dissection after positive sentinel node biopsy is being further investigated in an actively recruiting randomized trial. We elicited patients\u2019 preferences for axillary dissection versus no axillary dissection after positive sentinel node biopsy for early breast cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who had undergone axillary dissection after positive sentinel node biopsy as part of breast conserving therapy were provided with a validated, self\u2010rated questionnaire. The questionnaire comprised two trade\u2010off questions to determine the maximum chance of developing arm side\u2010effects from axillary dissection to justify the benefit of additional axillary staging information. Social, demographic, and clinical details were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010nine of the 126 eligible patients returned the questionnaire and 76 completed the trade\u2010off assessment. The median age of participants was 62 years. The median numbers of sentinel and axillary nodes removed were 2 and 12, respectively. Forty\u2010seven percent of participants had arm swelling or tenderness of any severity. Seventy\u2010five percent of participants would have axillary dissection even if the chance of arm side\u2010effects like they had experienced was 100%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Most patients with early breast cancer preferred axillary dissection after positive sentinel node biopsy for the additional staging information even though there was no survival benefit from axillary dissection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.13238","type":"journal-article","created":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T21:55:19Z","timestamp":1567029319000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Axillary dissection in sentinel lymph node positive breast cancer: Is the staging information worthwhile for patients?"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6699-5950","authenticated-orcid":false,"given":"David W.","family":"Chang","sequence":"first","affiliation":[{"name":"Division of Radiation Oncology and Cancer Imaging Peter MacCallum Cancer Centre  Melbourne Victoria Australia"},{"name":"Department of Radiation Oncology Nelune Comprehensive Cancer Centre, Prince of Wales Hospital  Randwick New South Wales Australia"},{"name":"Children's Cancer Institute Australia Lowy Cancer Research Centre University of New South Wales  Kensington New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Bressel","sequence":"additional","affiliation":[{"name":"Centre for Biostatistics and Clinical Trials Peter MacCallum Cancer Centre  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Hansen","sequence":"additional","affiliation":[{"name":"Mid North Coast Cancer Institute Port Macquarie Base Hospital  Port Macquarie New South Wales 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