{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T15:25:39Z","timestamp":1767626739633,"version":"3.40.5"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T00:00:00Z","timestamp":1572998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have been found to prolong survival in selected patients with peritoneal disease, but the extent of cytoreduction and chemoperfusion can result in systemic toxicities. We evaluate the incidence of perioperative hematological complications and its associated risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective analysis of a prospectively collected database of CRS\u2010HIPEC cases between April 2001 and October 2016 was performed. Patients were stratified based on the clinicopathological characteristics, perioperative incidence, grade, and duration of leukopenia (white blood cells\u00a0&lt;\u00a04000\/mm<jats:sup>3<\/jats:sup>), neutropenia (absolute neutrophils\u00a0&lt;\u00a02000\/mm<jats:sup>3<\/jats:sup>), and thrombocytopenia (platelets\u00a0&lt;\u00a0140\u00a0000\/mm<jats:sup>3<\/jats:sup>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred and thirty\u2010five CRS\u2010HIPEC were performed in 220 patients with peritoneal metastasis of colorectal, ovarian, primary peritoneal, appendiceal, or mesothelioma origins. The incidences of leukopenia, neutropenia, and thrombocytopenia were 15.3%, 3.8%, and 37.9%, respectively. Median time to onset was 1 day (0\u201016 days), 0 day (0\u20102 days), and 1 day (1\u20102 days), respectively, after operation. Median duration of leukopenia, neutropenia, and thrombocytopenia was 1 day (1\u20103 days), 1 day (1\u20102days), and 3 days (range 0\u201016 days), respectively. Age\u00a0&gt;\u00a060 (odds ratio [OR] 0.229 [95% CI: 0.105\u20100.502], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) and the use of prior chemotherapy (OR 2.46 [95% CI: 1.24, 4.83], <jats:italic>P<\/jats:italic>\u00a0=\u00a0.010) were independent risk factors for thrombocytopenia on multivariable logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hematological toxicities are common after hyperthermic intraperitoneal chemotherapy with thrombocytopenia being most common. Patients with age\u00a0&gt;\u00a060, and who have undergone chemotherapy, are at risk of these toxicities and should be closely monitored post CRS\u2010HIPEC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.13275","type":"journal-article","created":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T16:10:10Z","timestamp":1573056610000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Hematological toxicities associated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2569-1261","authenticated-orcid":false,"given":"Evelyn Y. T.","family":"Wong","sequence":"first","affiliation":[{"name":"Division of Surgical Oncology National Cancer Centre Singapore  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace H. 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