{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T22:55:52Z","timestamp":1752101752056,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,6,7]],"date-time":"2020-06-07T00:00:00Z","timestamp":1591488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Beijing Hope Run Special Fund of Cancer Foundation of China","award":["LC2017A19"],"award-info":[{"award-number":["LC2017A19"]}]},{"name":"Capital's Funds for Health Improvement and Research","award":["2016-2-4022"],"award-info":[{"award-number":["2016-2-4022"]}]},{"name":"Application of Clinical Features of Capital City of Science and Technology Commission China BEIJING Special subject","award":["Z151100004015120"],"award-info":[{"award-number":["Z151100004015120"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Natural orifice specimen extraction (NOSE) surgery has been widely implemented in colorectal cancer surgery due to its good short\u2010term efficacy. However, anastomotic leakage (AL) is a serious postoperative complication in colorectal cancer, and the risk factors for this complication after NOSE surgery have rarely been investigated. The aim of this study was to explore the predictive factors for AL after laparoscopic resection with transrectal NOSE for rectal cancer and sigmoid colon cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 208 patients who underwent total laparoscopic resection with transrectal NOSE for rectal cancer and sigmoid colon cancer from January 2014 to June 2019 were systematically reviewed. Univariate and multivariate analyses were performed to identify the relevant risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The rate of AL was 10.1% (21 of 208 patients). The univariate analyses showed that male sex (85.7%\u00a0vs 57.8%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.013), the distance from the anal verge (10.5\u00a0vs 14.5\u00a0cm, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.011), and a duration of operation \u2265140\u00a0min (71.4%\u00a0vs 29.4%, <jats:italic>P<\/jats:italic>&lt;.001) were associated with an increased incidence of AL. The multivariate analysis showed that a duration of operation \u2265140\u00a0min (OR\u00a0=\u00a05427, 95% CI\u00a0=\u00a01.355\u201021.727, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.017) was an independent risk factor for AL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A duration of operation \u2265140\u00a0min is a possible risk factor for AL after total laparoscopic resection with transrectal NOSE for colorectal cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.13372","type":"journal-article","created":{"date-parts":[[2020,6,7]],"date-time":"2020-06-07T13:51:20Z","timestamp":1591537880000},"page":"326-332","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluating the predictive factors for anastomotic leakage after total laparoscopic resection with transrectal natural orifice specimen extraction for colorectal cancer"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0420-2892","authenticated-orcid":false,"given":"Sicheng","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Colorectal Surgery National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Pei","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zijin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neonatology Tianjin Children's Hospital  Tianjin 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Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhixiang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xishan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing 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