{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T19:57:51Z","timestamp":1781294271600,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T00:00:00Z","timestamp":1597017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of the study was to compare the therapeutic strategies and prognostic factors of patients with primary intestinal diffuse large B\u2010cell lymphoma (PI\u2010DLBCL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 50 PI\u2010DLBCL patients who accepted standard first\u2010line treatment at National Cancer Center in China were included in this retrospective study. Survival analysis was performed to evaluate the prognostic risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 3\u2010year overall survival (OS) and 3\u2010year progression\u2010free survival (PFS) for the entire group were 76.0% and 65.9%, respectively. Univariate analysis showed that B symptom, advanced Lugano stage, elevated LDH status, poor ECOG PS and immunochemotherapy alone were significantly correlated with a poor PFS. Elevated LDH status, poor ECOG PS, advanced Lugano stage, high IPI score and immunochemotherapy alone were significantly correlated with a poor OS. Multivariate analysis revealed that ECOG PS (<jats:italic>P<\/jats:italic>=\u00a00.035; HR\u00a0=\u00a00.233; 95% CI, 0.060\u20130.905), LDH level (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.010; HR\u00a0=\u00a00.223; 95% CI, 0.072\u20130.693) and surgery (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002; HR\u00a0=\u00a05.584; 95% CI, 1.883\u201316.563) were independent prognostic factors for OS. LDH level (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.035; HR\u00a0=\u00a00.210; 95% CI, 0.049\u20130.894) and surgery (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003; HR\u00a0=\u00a06.410; 95% CI, 1.903\u201321.593) were independent risk factors for PFS in PI\u2010DLBCL. R\u2010CHOP immunochemotherapy combined surgery treatment was also associated with a lower rate of refractory\/relapsed (R\/R) disease (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.004). Furthermore, stratified analysis revealed that partial resection or radical resection combined with immunochemotherapy had no significantly difference which affect OS (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.338) and PFS (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.207).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>R\u2010CHOP immunochemotherapy plus surgery was associated with a superior prognosis compared with R\u2010CHOP alone in Chinese PI\u2010DLBCL population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.13396","type":"journal-article","created":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T06:15:34Z","timestamp":1597126534000},"page":"385-391","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["R\u2010CHOP immunochemotherapy plus surgery is associated with a superior prognosis in Chinese primary intestinal diffuse large B\u2010cell 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