{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:19:34Z","timestamp":1789049974093,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T00:00:00Z","timestamp":1600992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Primary central nervous system lymphoma (PCNSL) is rare disease and shows poor prognosis although methotrexate\u2010based chemotherapy is used. Here, we present our experiences with high\u2010dose methotrexate (HD\u2010MTX) monotherapy for immunocompetent patients with PCNSL at three institutions and investigate factors related to survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PCNSL patients, who were histologically confirmed with diffuse large B cells and treated with HD\u2010MTX monotherapy from 2001 to 2016, were retrospectively reviewed. Patients underwent induction chemotherapy with 8\u00a0g\/m<jats:sup>2<\/jats:sup> of MTX every 10 days (maximum three cycles). Maintenance chemotherapy of 3.5\u00a0g\/m<jats:sup>2<\/jats:sup> of MTX (maximum six cycles) was selectively performed depending on the response to induction chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 67 patients were included. Although seven patients discontinued induction chemotherapy because of MTX toxicity, 40 (59.7%) patients showed a complete response (CR) to induction chemotherapy. Twenty\u2010six (38.8%) and three (4.5%) patients showed a CR and partial response, respectively, after maintenance chemotherapy. Forty\u2010one patients with recurrence or progression following HD\u2010MTX underwent second\u2010line treatment. Progression\u2010free survival rates were 43% and 24% at 1 and 2 years, respectively. The median overall survival was 40.3 months. In a multivariate analysis, a radiological CR to induction chemotherapy was a significant factor related to prolonged progression\u2010free survival and overall survival (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MTX\u2010monotherapy is tolerable in terms of adverse effects and still considered as a treatment option in patients with PCNSL. However, an additional therapeutic option should be prepared for non\u2010CR responders to induction chemotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.13427","type":"journal-article","created":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T04:24:56Z","timestamp":1601094296000},"page":"123-130","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["High\u2010dose methotrexate monotherapy for newly diagnosed primary central nervous system lymphoma: 15\u2010year multicenter experience"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2504-4734","authenticated-orcid":false,"given":"Wan\u2010Soo","family":"Yoon","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Incheon St. Mary's Hospital College of Medicine The Catholic University of Korea  Incheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae\u2010Sung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Seoul St. Mary's Hospital College of Medicine The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u2010il","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery St. Vincent's Hospital College of Medicine The Catholic University of Korea  Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Sup","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Incheon St. Mary's Hospital College of Medicine The Catholic University of Korea  Incheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sin\u2010Soo","family":"Jeun","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Seoul St. Mary's Hospital College of Medicine The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010Kil","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Seoul St. Mary's Hospital College of Medicine The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Ho","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery St. Vincent's Hospital Cell Death Disease Research Center College of Medicine The Catholic University of Korea  Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nox158"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197410)34:4<1293::AID-CNCR2820340441>3.0.CO;2-P"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01052727"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200645090-00002"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000593"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61416-1"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2017.101"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-008-9736-9"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000300671.37279.0e"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-009-0090-3"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.11-6-694"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-014-2614-6"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2015-0164"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.17.3144"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.11.013"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70229-1"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2012.077917"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11771"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-0625"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24204"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31820f2d94"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-011-0608-3"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000125334.16420.D4"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq548"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-0159"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2011.060434"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2012.04.001"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/now033"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.08.2941"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.09.139"}],"container-title":["Asia-Pacific Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajco.13427","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajco.13427","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajco.13427","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T16:37:55Z","timestamp":1693759075000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajco.13427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,25]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1111\/ajco.13427"],"URL":"https:\/\/doi.org\/10.1111\/ajco.13427","archive":["Portico"],"relation":{},"ISSN":["1743-7555","1743-7563"],"issn-type":[{"value":"1743-7555","type":"print"},{"value":"1743-7563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,25]]},"assertion":[{"value":"2019-09-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}