{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:43:28Z","timestamp":1787013808119,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T00:00:00Z","timestamp":1599091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Colorectal cancer (CRC) is rising in incidence in young adults, and this observation is currently unexplained. We investigated whether having a personal history of type 2 diabetes mellitus (T2D) was a potential risk factor for young\u2010onset colorectal cancer (YOCRC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The South Australian Young Onset (SAYO) CRC study is a series of young adults with CRC below age 55. Ninety unrelated YOCRC cases were recruited to the study. Personal history and detailed family history of T2D were obtained at face\u2010to\u2010face interview and confirmed from medical records. Whole exome sequencing was conducted on germline DNA from each CRC case. Controls for personal history studies of T2D were 240 patients with proven clear colonoscopies and no known CRC predispositions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median age of YOCRC cases was 44 years (18\u201354) and of controls was 45 years (18\u201354), and 53% of both cases and controls were females (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.99). Left\u2010sided (distal) CRC was seen in 67\/89 (75%) of cases. A personal history of T2D was confirmed in 17\/90 (19%) YOCRC patients compared with controls (12\/240, 5%;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001; odds ratio = 4.4; 95% confidence interval, 2.0\u20139.7). YOCRC patients frequently reported at least one first\u2010degree relative with T2D (32\/85, 38%). Ten of 87 (12%) of YOCRC cases had CRC\u2010related pathogenic germline variants, however, no pathogenic variants in familial diabetes\u2010associated genes were seen.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Though the mechanism remains unclear, our observations suggest that there is enrichment for personal history of T2D in YOCRC patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Impact<\/jats:title>\n                    <jats:p>A diagnosis of T2D could therefore potentially identify a subset of young adults at increased risk for CRC and in whom early screening might be appropriate.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ajco.13428","type":"journal-article","created":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T02:23:15Z","timestamp":1599186195000},"page":"131-138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Young\u2010onset colorectal cancer is associated with a personal history of type 2 diabetes"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1765-0619","authenticated-orcid":false,"given":"Reger R.","family":"Mikaeel","sequence":"first","affiliation":[{"name":"Department of Haematology and Oncology The Queen Elizabeth Hospital  Woodville South South Australia Australia"},{"name":"SAHMRI Colorectal Node Basil Hetzel Institute  Woodville South South Australia Australia"},{"name":"Faculty of Health and Medical Sciences University of Adelaide  Adelaide South Australia Australia"},{"name":"Biology Department College of Science University of Duhok  Duhok Kurdistan Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin L.","family":"Symonds","sequence":"additional","affiliation":[{"name":"Bowel Health Service Flinders Medical Centre  Bedford Park South Australia Australia"},{"name":"Flinders Centre for Innovation in Cancer Flinders University  Bedford Park South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Kimber","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences University of Adelaide  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Haematology and Oncology The Queen Elizabeth Hospital  Woodville South South Australia Australia"},{"name":"University of Adelaide Department of Surgery The Queen Elizabeth Hospital  Woodville South South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehgan","family":"Horsnell","sequence":"additional","affiliation":[{"name":"Department of Haematology and Oncology The Queen Elizabeth Hospital  Woodville South South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Uylaki","sequence":"additional","affiliation":[{"name":"Department of Haematology and Oncology The Queen Elizabeth Hospital  Woodville South South Australia Australia"},{"name":"Department of Gastroenterology The Queen Elizabeth Hospital  Woodville South South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Tapia Rico","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Royal Adelaide Hospital  Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Hewett","sequence":"additional","affiliation":[{"name":"University of Adelaide Department of Surgery The Queen Elizabeth Hospital  Woodville South South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Yong","sequence":"additional","affiliation":[{"name":"University of Adelaide Department of Surgery The Queen Elizabeth Hospital  Woodville South South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren","family":"Tonkin","sequence":"additional","affiliation":[{"name":"University of Adelaide Department of Surgery The Queen Elizabeth Hospital  Woodville South South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Jesudason","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The Queen Elizabeth Hospital  Woodville South South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola K.","family":"Poplawski","sequence":"additional","affiliation":[{"name":"Adult Genetics Unit Royal Adelaide Hospital  Adelaide South Australia Australia"},{"name":"Discipline of Paediatrics Adelaide Medical School Faculty of Health and Medical Sciences University of Adelaide  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R.","family":"Ruszkiewicz","sequence":"additional","affiliation":[{"name":"Division of Anatomical Pathology SA Pathology  Adelaide South Australia Australia"},{"name":"Centre for Cancer Biology University of South Australia  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Drew","sequence":"additional","affiliation":[{"name":"University of Adelaide Department of Surgery The Queen Elizabeth Hospital  Woodville South South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny E.","family":"Hardingham","sequence":"additional","affiliation":[{"name":"Department of Haematology and Oncology The Queen Elizabeth Hospital  Woodville South South Australia Australia"},{"name":"SAHMRI Colorectal Node Basil Hetzel Institute  Woodville South South Australia Australia"},{"name":"Faculty of Health and Medical Sciences University of Adelaide  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Royal Adelaide Hospital  Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Frank","sequence":"additional","affiliation":[{"name":"Discipline of General Practice Adelaide Medical School Faculty of Health and Medical Sciences University of Adelaide  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Tomita","sequence":"additional","affiliation":[{"name":"Department of Haematology and Oncology The Queen Elizabeth Hospital  Woodville South South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dainik","family":"Patel","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences University of Adelaide  Adelaide South Australia Australia"},{"name":"Department of Medical Oncology Lyell McEwin Hospital  Elizabeth Vale South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sina","family":"Vatandoust","sequence":"additional","affiliation":[{"name":"Flinders Medical Centre  Bedford Park South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda R.","family":"Townsend","sequence":"additional","affiliation":[{"name":"Department of Haematology and Oncology The Queen Elizabeth Hospital  Woodville South South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6442-4409","authenticated-orcid":false,"given":"David","family":"Roder","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology and Population Health University of South Australia  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme P.","family":"Young","sequence":"additional","affiliation":[{"name":"Flinders Centre for Innovation in Cancer Flinders University  Bedford Park South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Parry","sequence":"additional","affiliation":[{"name":"New Zealand Familial GI Cancer Service Auckland City Hospital  Auckland New Zealand"},{"name":"National Bowel Screening Programme Ministry of Health  New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian P.","family":"Tomlinson","sequence":"additional","affiliation":[{"name":"Institute of Cancer and Genomic Sciences University of Birmingham  Edgbaston Birmingham United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Wittert","sequence":"additional","affiliation":[{"name":"Discipline of Medicine Faculty of Health and Medical Sciences University of Adelaide  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Wattchow","sequence":"additional","affiliation":[{"name":"Flinders University Flinders Medical Centre  Bedford Park South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel L.","family":"Worthley","sequence":"additional","affiliation":[{"name":"South Australian Health &amp; Medical Research Institute &amp; School of Medicine The University of Adelaide  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Brooks","sequence":"additional","affiliation":[{"name":"Adelaide Medical Solutions Adelaide Health Solutions  Woodville South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J.","family":"Price","sequence":"additional","affiliation":[{"name":"Department of Haematology and Oncology The Queen Elizabeth Hospital  Woodville South South Australia Australia"},{"name":"Faculty of Health and Medical Sciences University of Adelaide  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne P.","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Haematology and Oncology The Queen Elizabeth Hospital  Woodville South South Australia Australia"},{"name":"SAHMRI Colorectal Node Basil Hetzel Institute  Woodville South South Australia Australia"},{"name":"Faculty of Health and Medical Sciences University of Adelaide  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12792"},{"issue":"1","key":"e_1_2_8_3_1","article-title":"Colorectal cancer in Australian Young Adults Mathews","volume":"4","author":"Mikaeel RR","year":"2019","journal-title":"J Cancer Sci"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-09-0186"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djw322"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e3181881354"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-004-7306-7"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2012.10.016"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clcc.2015.07.005"},{"key":"e_1_2_8_10_1","first-page":"59","article-title":"Cancer in Australia 2017: Cancer Series 101","author":"AIHW","year":"2017","journal-title":"In Cancer series Canberra"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja12.11357"},{"key":"e_1_2_8_12_1","unstructured":"Screening strategies for people with a family history of colorectal cancer [article online] 2017. Available fromhttps:\/\/wiki.cancer.org.au\/australia\/Guidelines:Colorectal_cancer\/Screening_based_on_family_history. Accessed February 28 2019."},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.5194"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2017.07.016"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-015-4005-1"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g7607"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2015.05.021"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-18-0159"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.09.041"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep46527"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001988"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-017-0612-y"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-02-832253"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2015.30"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes6010087"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(18)30051-2"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.20.4.1043"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh034"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djz098"},{"key":"e_1_2_8_30_1","unstructured":"Diabetes Compendium [article online] 2017. Available fromhttps:\/\/www.aihw.gov.au\/reports\/diabetes\/diabetes-compendium\/contents\/how-many-australians-have-diabetes. Accessed February 28 2019."},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20194915"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-018-3191-7"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i17.5167"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i22.6946"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000669"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-2817"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/gidisord1020023"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aao5774"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-018-4632-0"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwf112"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.6.542"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-16-0761"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.12.029"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-1175"}],"container-title":["Asia-Pacific Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajco.13428","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajco.13428","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajco.13428","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T12:38:36Z","timestamp":1693744716000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajco.13428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,3]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1111\/ajco.13428"],"URL":"https:\/\/doi.org\/10.1111\/ajco.13428","archive":["Portico"],"relation":{},"ISSN":["1743-7555","1743-7563"],"issn-type":[{"value":"1743-7555","type":"print"},{"value":"1743-7563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,3]]},"assertion":[{"value":"2020-03-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}