{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:53:17Z","timestamp":1792133597827,"version":"4.4.0"},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T00:00:00Z","timestamp":1601164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Immune checkpoint inhibitors (ICI) have improved survival across tumor types however they cause immune\u2010related toxicities through removal of the inhibition of auto\u2010reactive T cells. In this case review, we present 4 patients with metastatic cancer who developed de\u2010novo neuromuscular side effects of myositis with overlapping seropositive myasthenia gravis after ICI treatment. Declaration: This study was performed in accordance to the ethical standards set by the SingHealth Institutional Review Board, with consent taken from living patients and waiver of consent from deceased patients (CIRB Ref 2019\/2485). Supporting data were collected from our institution's digital medical records system.<\/jats:p>","DOI":"10.1111\/ajco.13442","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T06:44:14Z","timestamp":1601275454000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Immune checkpoint inhibitor\u2010associated myositis and myasthenia gravis overlap: Understanding the diversity in a case series"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2569-1261","authenticated-orcid":false,"given":"Evelyn Yi Ting","family":"Wong","sequence":"first","affiliation":[{"name":"Division of Medical Oncology National Cancer Centre Singapore  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming Hui","family":"Yong","sequence":"additional","affiliation":[{"name":"Department of Neurology National Neuroscience Institute \u2013 Singapore General Hospital Campus  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kok Pin","family":"Yong","sequence":"additional","affiliation":[{"name":"Department of Neurology National Neuroscience Institute \u2013 Singapore General Hospital Campus  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eng Huat","family":"Tan","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology National Cancer Centre Singapore  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chee Keong","family":"Toh","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology National Cancer Centre Singapore  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravindran","family":"Kanesvaran","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology National Cancer Centre Singapore  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Takano","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology Singapore General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan Sing","family":"Ng","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology National Cancer Centre Singapore  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,27]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1703481"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2019.0013"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1611299"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.66.1389"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004359"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-018-0878-7"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.035898"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1402225"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-019-0617-x"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2016.12.001"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw443"}],"container-title":["Asia-Pacific Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajco.13442","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajco.13442","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajco.13442","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T21:56:56Z","timestamp":1693346216000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajco.13442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,27]]},"references-count":11,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1111\/ajco.13442"],"URL":"https:\/\/doi.org\/10.1111\/ajco.13442","archive":["Portico"],"relation":{},"ISSN":["1743-7555","1743-7563"],"issn-type":[{"value":"1743-7555","type":"print"},{"value":"1743-7563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,27]]},"assertion":[{"value":"2020-06-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}