{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T23:08:55Z","timestamp":1782256135522,"version":"3.54.5"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T00:00:00Z","timestamp":1614211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aims to determine the frequency of germline <jats:italic>BRCA<\/jats:italic> 1\/2 mutations in Turkish women with epithelial ovarian cancer (EOC) and evaluate its relationship with clinicopathological characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this cross\u2010sectional study, all women with recently diagnosed EOC presenting to Zekai Tahir Burak Women's Health Training and Research Hospital Medical Oncology Clinic between 2016 and 2019 were referred for <jats:italic>BRCA<\/jats:italic> testing. Peripheral blood samples were obtained from 76 patients applying to Medical Genetics and <jats:italic>BRCA1\/2<\/jats:italic> genes were sequenced using next\u2010generation sequencing. The American College of Medical Genetics and Genomics 2015 criteria were followed for classification of genetic variants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010four women (31.6%) had pathogenic germline <jats:italic>BRCA1\/2<\/jats:italic> mutations. Of these, 17 patients (22.4%) harbored germline <jats:italic>BRCA1<\/jats:italic> mutations and 7 (9.2%) had <jats:italic>BRCA2<\/jats:italic> mutations. When we compared the patients with and without <jats:italic>BRCA<\/jats:italic> mutations, there was significant difference in terms of family history (41.7% vs 9.6%, respectively, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001). Among all patients, 15 (19.7%) had history of breast or ovarian cancer in first\u2010 or second\u2010degree relatives. Germline <jats:italic>BRCA1\/2<\/jats:italic> mutations were detected in 66.7% of patients with family history, while these mutations were found in 22.9% of patients without family history (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this sample 31.6% of Turkish women with EOC harbored germline <jats:italic>BRCA<\/jats:italic>1\/2 mutations, which seems higher compared to other ethnic groups except for the Ashkenazi Jews population. All women with EOC should be referred for <jats:italic>BRCA<\/jats:italic> testing regardless of family history, age at diagnosis, and histological subtype.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.13520","type":"journal-article","created":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T09:55:00Z","timestamp":1614246900000},"page":"84-92","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Frequency of germline <i>BRCA1\/2<\/i> mutations and association with clinicopathological characteristics in Turkish women with epithelial ovarian cancer"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4672-4621","authenticated-orcid":false,"given":"Veli","family":"Sunar","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Zekai Tahir Burak Women's Health Research and Education Hospital Faculty of Medicine University of Health Sciences  Ankara 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