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Moreover, TOX+PD\u20101+ and TOX+Tim\u20103+ double\u2010positive T cells increased among the CD3+, CD4+, and CD8+T cell populations in the B\u2010NHL group. There was apparent heterogeneity in TOX expression and co\u2010expression with PD\u20101, Tim\u20103, and CD244 in CD3+, CD4+, and CD8+ T cells in different lymphoma patients. In addition, the percentage of CD4+CD25+FoxP3+ T cells (Treg) among the CD3+ and CD4+ T cells significantly increased, and the number of TOX+ and TOX+PD\u20101+ Treg cells also significantly increased in the B\u2010NHL group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Higher expression of TOX concurrent with PD\u20101, Tim\u20103, and CD244 in T cells from patients with B\u2010NHL may contribute to T cell exhaustion and impair their special anti\u2010tumor T cell activity. TOX may be considered a potential target for reversing T cell exhaustion and improving T cell function in hematological malignancies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.13545","type":"journal-article","created":{"date-parts":[[2021,2,21]],"date-time":"2021-02-21T02:10:13Z","timestamp":1613873413000},"page":"143-149","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Increased TOX expression concurrent with PD\u20101, Tim\u20103, and CD244 in T cells from patients with non\u2010Hodgkin lymphoma"],"prefix":"10.1111","volume":"18","author":[{"given":"Shuxin","family":"Huang","sequence":"first","affiliation":[{"name":"Institute of Hematology School of Medicine Key Laboratory for Regenerative Medicine of Ministry of Education Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaofeng","family":"Liang","sequence":"additional","affiliation":[{"name":"Institute of 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