{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T17:01:08Z","timestamp":1776272468219,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T00:00:00Z","timestamp":1624406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>PSMA PET\/CT has demonstrated superior sensitivity over conventional imaging in the detection of local and distant recurrence in biochemically relapsed (BCR) prostate cancer. We prospectively investigated the management impact of<jats:sup>68<\/jats:sup>Ga\u2010PSMA PET\/CT imaging in men with BCR, with the aim of identifying baseline clinicopathological predictors for management change.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Men with BCR who met eligibility criteria underwent<jats:sup>68<\/jats:sup>Ga\u2010PSMA\u201011 PET\/CT at Monash Health (Melbourne, Australia). Intended management plans were prospectively documented before and after<jats:sup>68<\/jats:sup>Ga\u2010PSMA PET\/CT imaging. Binary logistic regression analysis was performed to identify potential clinicopathological predictors of management change. Descriptive statistics were used to characterize the nature of these changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy men underwent<jats:sup>68<\/jats:sup>Ga\u2010PSMA\u201011 PET\/CT imaging. Median age was 67 years (IQR 63\u201372) and median PSA was 0.48\u00a0ng\/ml (IQR 0.21\u20131.9). PSMA\u2010avid disease was observed in 56% (39\/70) of patients. Pre\u2010scan management plan was altered following scanning in 43% (30\/70) of patients. Management changes were significantly more common in patients with higher baseline PSA levels (PSA\u22652\u00a0ng\/ml,<jats:italic>p\u00a0<\/jats:italic>=\u00a00.01). 18\/36 (50%) of the patients initially planned for watchful waiting had their management changed, including the use of salvage pelvic radiotherapy (<jats:italic>n<\/jats:italic>\u00a0=\u00a07) and stereotactic ablative body radiotherapy to oligometastatic disease (<jats:italic>n<\/jats:italic>\u00a0=\u00a06).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Management change after<jats:sup>68<\/jats:sup>Ga\u2010PSMA PET\/CT for BCR is common and typically resulted in treatment intensification strategies in those planned for a watchful waiting approach. This study adds to the growing pool of evidence supporting the clinical utility of PSMA PET\/CT imaging in the care of patients with BCR after definitive therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.13595","type":"journal-article","created":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T17:22:10Z","timestamp":1624468930000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<sup>68<\/sup>Ga\u2010prostate\u2010specific membrane antigen (PSMA) PET\/CT as a clinical decision\u2010making tool in biochemically recurrent prostate cancer"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3848-5501","authenticated-orcid":false,"given":"Amy","family":"Davies","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Monash Health Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Foo","sequence":"additional","affiliation":[{"name":"GenesisCare Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun Loo","family":"Gan","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Monash Health Melbourne Victoria Australia"},{"name":"Tom Baker Cancer Center University of Calgary Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Kourambas","sequence":"additional","affiliation":[{"name":"Department of Urology Monash Health Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Redgrave","sequence":"additional","affiliation":[{"name":"Department of Urology Monash Health Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Donnellan","sequence":"additional","affiliation":[{"name":"Department of Urology Monash Health Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sree","family":"Appu","sequence":"additional","affiliation":[{"name":"Department of Surgery Monash Health Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Williams","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology and Cancer Imaging Peter MacCallum Cancer Centre Melbourne Victoria Australia"},{"name":"Sir Peter MacCallum Department of Oncology University of Melbourne Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Coleman","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology and Cancer Imaging Peter MacCallum Cancer Centre Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Segelov","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Monash Health Melbourne Victoria Australia"},{"name":"Department of Medicine, School of Clinical Sciences Monash University Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Bradley","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine &amp; 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