{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:36:36Z","timestamp":1747182996737,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T00:00:00Z","timestamp":1624924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Breast cancer (BC) is the most common cancer in Malaysia, with incidence increasing with age. There have been demonstrated differences in age of presentation and tumour biology when comparing ethnicities. Twenty percent of Caucasian women present before 50 years old, but almost 50% of Southeast Asian (SEA) women present before 50. However, BC in Indigenous sub\u2010groups has not yet been studied. Sandakan is a city in Sabah with a large Indigenous population. Current nationwide screening guidelines are based on the U.S. Preventive Task Force 2009 Guidelines, which may not represent our population. We aim to examine the age of incidence for our local population, for local screening recommendations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Retrospective cross\u2010sectional study, including all consecutive cases of epithelial invasive tumours, from January 2016 to December 2018. Other histological types were excluded. Univariate and multivariate analyses were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>A total of 115 breast tumours were identified. Ten tumours were excluded (five ductal carcinoma in situ, four phyllodes, and one sarcoma), leaving a study population of 105 patients. Median age of presentation was 53 years (min 30; max 97). A total of 41.9% presented before the age of 50. Patients of Indigenous ethnic origins were 11\u00a0years younger at presentation than non\u2010Indigenous women. Tumour grade was more likely to be higher among Indigenous women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Median age of presentation of BC in Sandakan matches regional data; however, patients of Indigenous ethnic groups present even earlier. Screening guidelines should consider the growing evidence of young BC in SEA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.13596","type":"journal-article","created":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T19:30:12Z","timestamp":1624995012000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Young breast cancer and the influence of ethnicity in Sandakan: A 3\u2010year retrospective cross\u2010sectional study"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4755-859X","authenticated-orcid":false,"given":"Wei Jin","family":"Wong","sequence":"first","affiliation":[{"name":"Department of General Surgery University of Malaya Medical Centre  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syaza Putri","family":"Zainudin","sequence":"additional","affiliation":[{"name":"Department of General Surgery Faculty of Medicine and Health Sciences University Malaysia Sabah  Kota Kinabalu Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yee Hoong","family":"Koo","sequence":"additional","affiliation":[{"name":"Department of General Surgery Duchess of Kent Hospital  Sandakan Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kah Yee","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of General Surgery Duchess of Kent Hospital  Sandakan Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong Jie","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of General Surgery Duchess of Kent Hospital  Sandakan Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwong Hui","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of General Surgery Duchess of Kent Hospital  Sandakan Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,29]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"National Cancer Institute.Malaysian National Cancer Registry Report 2007 \u2010 2011.National Cancer Institute;2016."},{"key":"e_1_2_9_3_1","unstructured":"Cancer Today.International Agency for Research on Cancer.Cancer Today;2019.https:\/\/gco.iarc.fr\/. Accessed March 29 2019."},{"key":"e_1_2_9_4_1","unstructured":"American Cancer Society.Breast Cancer Facts & Figures 2017\u20132018.Atlanta:American Cancer Society; Retrieved fromhttps:\/\/www.cancer.org\/research\/cancer\u2010facts\u2010statistics\/breast\u2010cancer\u2010facts\u2010figures.html. Accessed March 29 2019."},{"key":"e_1_2_9_5_1","unstructured":"Cancer Research UK.Breast Cancer Incidence (Invasive) Statistics.Cancer Research UK;2019.https:\/\/www.cancerresearchuk.org\/health\u2010professional\/cancer\u2010statistics\/statistics\u2010by\u2010cancer\u2010type\/breast\u2010cancer. Accessed March 29 2019."},{"issue":"2","key":"e_1_2_9_6_1","first-page":"101","article-title":"Incidence and mortality of female breast cancer in the Asia\u2010Pacific region","volume":"11","author":"Youlden DR","year":"2014","journal-title":"Cancer Biol Med"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2011.01.015"},{"key":"e_1_2_9_8_1","first-page":"525","article-title":"Breast cancer in Sabah, Malaysia: a two year prospective study","volume":"8","author":"Leong B","year":"2007","journal-title":"Asian Pac J Cancer Prev"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.11109"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2016.68"},{"key":"e_1_2_9_11_1","unstructured":"Ministry of Health Malaysia.Malaysian Clinical Practice Guidelines on Management of Breast Cancer.2nd ed.Ministry of Health Malaysia;2010."},{"key":"e_1_2_9_12_1","unstructured":"World Directory of Minorities and Indigenous People.Indigenous Peoples and Ethnic Minorities in Sabah.https:\/\/minorityrights.org\/minorities\/indigenous\u2010peoples\u2010and\u2010ethnic\u2010minorities\u2010in\u2010sabah\/. Accessed March 1 2019."},{"key":"e_1_2_9_13_1","unstructured":"Department of Statistics Malaysia.Official Portal.dosm.gov.my\/v1\/. Accessed May 2 2020."},{"key":"e_1_2_9_14_1","unstructured":"City Population.https:\/\/www.citypopulation.de\/php\/malaysia\u2010admin.php?adm2id=1204. Accessed February 28 2019."},{"key":"e_1_2_9_15_1","unstructured":"Ministry of Health.Hospital Duchess of Kent Sandakan.https:\/\/hdok.moh.gov.my\/v8\/?q=mhosp. Accessed May 28 2020."},{"key":"e_1_2_9_16_1","unstructured":"World Health Organization.Indigenous Populations.https:\/\/www.who.int\/topics\/health_services_indigenous\/en\/. 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