{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T01:18:13Z","timestamp":1783387093385,"version":"3.54.6"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T00:00:00Z","timestamp":1637625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Gastric cancer with peritoneal involvement has a poor prognosis. Intraperitoneal (IP) paclitaxel has shown promising results in these patients. However, this approach has only been studied in the Asian population, and in combination with S\u20101. We investigated the maximum tolerated dose of IP paclitaxel, with a standard chemotherapy combination, in the Australian population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study of the population included metastatic human epidermal growth factor receptor 2 (HER2) negative gastric adenocarcinoma with peritoneal involvement. Treatment included six 21\u2010day cycles of cisplatin (80\u00a0mg\/m<jats:sup>2<\/jats:sup> IV, day 1) plus capecitabine (1000\u00a0mg\/m<jats:sup>2<\/jats:sup> PO BD, days 1\u201314) plus IP paclitaxel (days 1 and 8). IP paclitaxel doses for cohort 1\u20133 were 10, 20, and 30\u00a0mg\/m<jats:sup>2<\/jats:sup>, respectively, in a 3 + 3 standard dose\u2010escalation design.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifteen patients were enrolled of which 6 were female and the median age was 63. Two patients developed dose\u2010limiting toxicities. No grade 4\/5 toxicities were recorded. The maximum tolerated dose was not reached. Therefore, as defined by the study protocol, the recommended phase\u20102 dose for IP paclitaxel was determined to be 30\u00a0mg\/m<jats:sup>2<\/jats:sup>. The 12\u2010month survival rate was 46.7%, and the median survival was 11.5 months (interquartile range [IQR]: 15.3\u20136.9).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>IP paclitaxel is safe in combination with cisplatin and capecitabine and the recommended phase\u20102 dose is 30\u00a0mg\/m<jats:sup>2<\/jats:sup>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.13659","type":"journal-article","created":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T08:07:49Z","timestamp":1637654869000},"page":"404-409","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Phase 1 trial of intraperitoneal paclitaxel in combination with intravenous cisplatin and oral capecitabine in patients with advanced gastric cancer and peritoneal metastases (IPGP study)"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4815-0994","authenticated-orcid":false,"given":"Sina","family":"Vatandoust","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Flinders Medical Centre  Bedford Park Australia"},{"name":"College of Medicine and Public Health Flinders University  Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Bright","sequence":"additional","affiliation":[{"name":"College of Medicine and Public Health Flinders University  Adelaide Australia"},{"name":"Oesophago\u2010Gastric Surgical Unit Flinders Medical Centre  Bedford Park Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amitesh Chandra","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Flinders Medical Centre  Bedford Park Australia"},{"name":"College of Medicine and Public Health Flinders University  Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1562-3708","authenticated-orcid":false,"given":"Muhammad Nazim","family":"Abbas","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Flinders Medical Centre  Bedford Park Australia"},{"name":"College of Medicine and Public Health Flinders University  Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Ian","family":"Watson","sequence":"additional","affiliation":[{"name":"College of Medicine and Public Health Flinders University  Adelaide Australia"},{"name":"Oesophago\u2010Gastric Surgical Unit Flinders Medical Centre  Bedford Park Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Gan","sequence":"additional","affiliation":[{"name":"College of Medicine and Public Health Flinders University  Adelaide Australia"},{"name":"Oesophago\u2010Gastric Surgical Unit Flinders Medical 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