{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T10:22:14Z","timestamp":1770459734807,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T00:00:00Z","timestamp":1643587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>Due to difficulties in identifying sufficient\u2010sized cohorts there remains uncertainty about prognostic and clinical differences that may be unique to asbestos\u2010related lung cancer (ARLC). In this study, we use the Helsinki Criteria to define a group of ex\u2010workers with lung cancer attributable to asbestos exposure and investigate differences that may exist.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 529 patients seeking workers\u2019 compensation for their lung cancer were assigned to either ARLC or the non\u2010ARLC based on parameters defined in the Helsinki Criteria. Clinical and survival details were collected and analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In our study population, ARLC patients were on average older (72.1 \u00b1\u00a07.8) than non\u2010ARLC patients (66.5\u00a0\u00b1\u00a010.2, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001) and were more likely to be diagnosed as a result of incidental findings or screening program (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001). The groups were similar in terms of clinical characteristics with the only difference being that plaques were more prevalent among ARLC patients (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Differences were observed for median overall survival (OS), ARLC (9 months) and non\u2010ARLC (13 months, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.005), as well for treatment (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.01). After adjusting for age, however, these differences disappeared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Age at diagnosis, pleural plaques, and asymptomatic presentation were the attributes that we identified as significantly different between asbestos\u2010related cancer and other lung cancers. In this cohort, ARLC patients were older diagnosis and with worse overall survival.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.13664","type":"journal-article","created":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T19:04:05Z","timestamp":1643655845000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Asbestos\u2010related lung cancer: Clinical characteristics and survival outcomes in an Australian cohort seeking workers compensation"],"prefix":"10.1111","volume":"18","author":[{"given":"Rebecca A","family":"Hyland","sequence":"first","affiliation":[{"name":"Asbestos Diseases Research Institute  Rhodes New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agata","family":"Chrzanowska","sequence":"additional","affiliation":[{"name":"Asbestos Diseases Research Institute  Rhodes New South Wales Australia"},{"name":"Sydney School of Public Health The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsty","family":"Hannaford\u2010Turner","sequence":"additional","affiliation":[{"name":"Research and Education Unit Icare Dust Disease Authority  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Chris O'Brien Lifehouse  Camperdown New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Ke","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Chris O'Brien Lifehouse  Camperdown New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Bradbury","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology The Crown Princess Mary Cancer Centre Westmead  Wentworthville New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adnan","family":"Nagrial","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology The Crown Princess Mary Cancer Centre Westmead  Wentworthville New South Wales Australia"},{"name":"Sydney Medical School The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"McCaughan","sequence":"additional","affiliation":[{"name":"Sydney Cardiothoracic Surgeons RPAH Medical Centre  Newtown New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rina","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology The Crown Princess Mary Cancer Centre Westmead  Wentworthville New South Wales Australia"},{"name":"Sydney Medical School The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nico","family":"van Zandwijk","sequence":"additional","affiliation":[{"name":"Asbestos Diseases Research Institute  Rhodes New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Asbestos Diseases Research Institute  Rhodes New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven C","family":"Kao","sequence":"additional","affiliation":[{"name":"Asbestos Diseases Research Institute  Rhodes New South Wales Australia"},{"name":"Sydney Medical School The University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Medical Oncology Chris O'Brien Lifehouse  Camperdown New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,31]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"WHO Media Centre: Cancer Fact Sheet[http:\/\/www.who.int\/mediacentre\/factsheets\/fs297\/en\/Accessed:29 May 2017."},{"key":"e_1_2_8_3_1","unstructured":"Australian Government; 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