{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T03:28:07Z","timestamp":1789702087158,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T00:00:00Z","timestamp":1637625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>A large proportion of cancer patients are at high risk for chemotherapy\u2010induced nausea and vomiting (CINV), but the choice of anti\u2010emetics for CINV in Malaysia is limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a real\u2010world study of a fixed\u2010dose combination of netupitant and palonosetron (NEPA) to inhibit CINV in adult patients receiving moderately (MEC) or highly emetogenic chemotherapy (HEC) for solid\/hematological malignancies at eight Malaysian centers. Each HEC\/MEC cycle received one dose of NEPA + dexamethasone for CINV prevention. Complete response (no emesis, no rescue medication) (CR), no more than mild nausea (severity score\u00a0\u2264\u00a02.5), and complete control (CR) (no more than mild nausea) during the acute (0\u201324\u00a0h), delayed (25\u2013120\u00a0h), and overall (0\u2013120\u00a0h) phases post\u2010chemotherapy were measured. Treatment\u2010related adverse events (AEs) were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During March 2016\u2013April 2018 (NMRR\u201017\u20103286\u201038282), NEPA + dexamethasone was administered to 54 patients (77.8% solid, 22.2% hematological malignancies). Note that 59.3% received HEC, while 40.7% received MEC regimen. During the overall phase of the first cycle, the majority had CR (77.8%), no more than mild nausea (74.1%), and complete control (61.1%). Seventeen patients received two consecutive cycles at any point of chemotherapy cycles. During the overall phases across two consecutive cycles, all patients achieved CR, and the majority reported no more than mild nausea and complete control. No grades 3\u20134 AEs were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>NEPA had sustained efficacy and tolerability at first administration and across two cycles of MEC\/HEC for CINV prevention.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.13667","type":"journal-article","created":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T08:08:06Z","timestamp":1637654886000},"page":"419-427","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Real\u2010world multicenter study of the safety and efficacy of netupitant plus palonosetron fixed\u2010dose combination to prevent chemotherapy\u2010induced nausea and vomiting among Malaysian patients receiving moderately or highly emetogenic chemotherapy"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8634-0468","authenticated-orcid":false,"given":"Mastura","family":"Md Yusof","sequence":"first","affiliation":[{"name":"Pantai Hospital Kuala Lumpur  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matin Mellor","family":"Abdullah","sequence":"additional","affiliation":[{"name":"Subang Jaya Medical Centre  Subang Jaya Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beng Khiong","family":"Yap","sequence":"additional","affiliation":[{"name":"Subang Jaya Medical Centre  Subang Jaya Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Chin","family":"Ng","sequence":"additional","affiliation":[{"name":"Subang Jaya Medical Centre  Subang Jaya Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Seng Hooi","family":"Low","sequence":"additional","affiliation":[{"name":"Pantai Hospital Kuala Lumpur  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai Seng","family":"Lam","sequence":"additional","affiliation":[{"name":"Pantai Hospital Kuala Lumpur  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radzi Bin Ahmad","family":"Ahmad Badruddin","sequence":"additional","affiliation":[{"name":"Dr A. Radzi's Integrated Oncology Clinic and Daycare Centre  Johor Bahru Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina Nye Bing","family":"Lai","sequence":"additional","affiliation":[{"name":"Sunway Medical Centre  Petaling Jaya Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kah Liew","family":"Lau","sequence":"additional","affiliation":[{"name":"Borneo Medical Centre  Kuching Sarawak Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang Jeat","family":"Chong","sequence":"additional","affiliation":[{"name":"Mahkota Medical Centre  Melaka Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel Gabriel","family":"Nonis","sequence":"additional","affiliation":[{"name":"Pantai Hospital Ayer Keroh  Melaka Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Azrif","family":"Ahmad Annuar","sequence":"additional","affiliation":[{"name":"Prince Court Medical Centre  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Haris Fadzillah Bin","family":"Abdul Rahman","sequence":"additional","affiliation":[{"name":"Subang Jaya Medical Centre  Subang Jaya Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,23]]},"reference":[{"issue":"9","key":"e_1_2_7_2_1","first-page":"1","article-title":"Clinical roundtable monograph: new data in emerging treatment options for chemotherapy\u2010induced nausea and vomiting","volume":"12","author":"Morrow GR","year":"2014","journal-title":"Clin Adv Hematol Oncol"},{"issue":"2","key":"e_1_2_7_3_1","first-page":"240","article-title":"Use of antiemetics in the prevention of chemotherapy\u2010induced nausea and vomiting: review and focus on the Belgian situation","volume":"77","author":"Van den Brande J","year":"2014","journal-title":"Acta Gastroenterol Belg"},{"key":"e_1_2_7_4_1","first-page":"175","article-title":"The impact of 5\u2010hydroxytryptamine\u2010receptor antagonists on chemotherapy treatment adherence, treatment delay, and nausea and vomiting","volume":"7","author":"Palli SR","year":"2015","journal-title":"Cancer Manag Res"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2014.15.13.5305"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw270"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2017.0117"},{"key":"e_1_2_7_8_1","unstructured":"Summary of product characteristics (Akynzeo). European Medicines Agency. Accessed February 20 2018.http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/EPAR_\u2010_Product_Information\/human\/003728\/WC500188432.pdf"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2012.06.010"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2012.30.15_suppl.9054"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2012.01.046"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon.14.260"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.7573\/dic.212298"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-015645"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-016-3080-y"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28892"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx698"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-016-3502-x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx100"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S89215"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2017.02.017"},{"key":"e_1_2_7_22_1","first-page":"713","article-title":"Update on the management of chemotherapy\u2010induced nausea and vomiting \u2013 focus on palonosetron","volume":"11","author":"Zhou M","year":"2015","journal-title":"Ther Clin Risk Manag"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-005-0788-5"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20230"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjspcare\u20102019\u2010002037"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-017-3585-z"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon.10.74"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.2217\/cer-2018-0089"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1158\/1538\u20107445.SABCS18\u2010P1\u201011\u201010"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.2091"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnr2.1127"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20004"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1200\/JGO.17.00229"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.4103\/1817-1737.91556"}],"container-title":["Asia-Pacific Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajco.13667","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajco.13667","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajco.13667","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:54:27Z","timestamp":1692838467000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajco.13667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,23]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1111\/ajco.13667"],"URL":"https:\/\/doi.org\/10.1111\/ajco.13667","archive":["Portico"],"relation":{},"ISSN":["1743-7555","1743-7563"],"issn-type":[{"value":"1743-7555","type":"print"},{"value":"1743-7563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,23]]},"assertion":[{"value":"2021-07-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}