{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:51:27Z","timestamp":1791805887666,"version":"4.3.4"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,1,30]],"date-time":"2022-01-30T00:00:00Z","timestamp":1643500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Little is known about the expression of immune checkpoint receptors in the peripheral blood of lymphoma patients. Herein, we assessed the expression of inhibitory checkpoint receptors, including CTLA\u20104, PD\u20101\/PDL\u20101, LAG\u20103, and TIM\u20103 in the peripheral blood of lymphoma patients and its correlation with the clinical outcomes of patients. Therefore, 47 classical Hodgkin lymphoma (cHL), 48 non\u2010Hodgkin lymphoma patients with diffuse large B\u2010cell lymphoma (DLBCL) subtype, and 30 healthy controls were recruited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The expression of inhibitory receptors was evaluated using SYBR Green real\u2010time PCR method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CTLA\u20104, LAG\u20103, and TIM\u20103 genes were significantly upregulated in both cHL and DLBCL patients compared to the healthy controls. In addition, the level of these molecules was differentially expressed in cHL and DLBCL patients at different disease phases compared to the healthy controls. The CTLA\u20104 gene was highly expressed in newly diagnosed (ND) cHL patients compared to the relapsed ones. Relapsed DLBCL patients had significantly increased LAG\u20103 expression compared to patients at remission, as well as ND patients. Regarding cHL patients, high CTLA\u20104 expression was correlated with low lactate dehydrogenase level and better performance status, whereas the level of LAG\u20103 was significantly elevated in patients with poor performance status. Lower initial PD\u20101 expression was associated with improved disease\u2010free survival in cHL patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Inhibitory immune checkpoint receptors are aberrantly expressed in the peripheral blood of cHL and DLBCL patients in which high LAG\u20103 in DLBCL patients and PD\u20101\/LAG\u20103 in cHL patients are associated with relapse occurrence and worse prognosis, respectively.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.13730","type":"journal-article","created":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T03:54:45Z","timestamp":1643601285000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The prognostic significance of immune checkpoint receptor expression in patients with lymphoma: Association with disease status and clinical outcomes"],"prefix":"10.1111","volume":"18","author":[{"given":"Negin","family":"Shokrgozar","sequence":"first","affiliation":[{"name":"Hematology Research Center Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2979-0865","authenticated-orcid":false,"given":"Mehdi","family":"Dehghani","sequence":"additional","affiliation":[{"name":"Hematology Research Center Shiraz University of Medical Sciences  Shiraz Iran"},{"name":"Department of Hematology and Medical Oncology Shiraz University of Medical Sciences  Namazi Hospital Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Golmoghaddam","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Medicine Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Moghadam","sequence":"additional","affiliation":[{"name":"Hematology Research Center Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narges","family":"Rezaei","sequence":"additional","affiliation":[{"name":"Hematology Research Center Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vida","family":"Moayed","sequence":"additional","affiliation":[{"name":"Hematology Research Center Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6489-0979","authenticated-orcid":false,"given":"Nargess","family":"Arandi","sequence":"additional","affiliation":[{"name":"Hematology Research Center Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,30]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60605-9"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2542"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.3MR0315-136R"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2017.04.004"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2017.184192"},{"key":"e_1_2_12_7_1","first-page":"756353","article-title":"Role of immune escape mechanisms in Hodgkin's lymphoma development and progression: a whole new world with therapeutic implications","author":"la","year":"2012","journal-title":"Clin Dev Immunol"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-1972"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20082492"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1160062"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni0702-611"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200323382"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2011.540563"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201344413"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.2.688"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12520"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3862"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/415536a"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1790"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.192461099"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.05.001"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12519"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.06.001"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1643"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.150656"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00054"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2016.03.005"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20090397"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.18632\/genesandcancer.180"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.26771"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajco.12850"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2017006346"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-4622-5"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2009.03.025"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2015.132761"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-8722-6-74"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-012-0176-1"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12144"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-020-02591-y"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.7.4180"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2011.03439.x"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2011.03539.x"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-1339"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-018-0191-1"},{"key":"e_1_2_12_45_1","first-page":"269","article-title":"LAG\u20103 in cancer immunotherapy","volume":"344","author":"Goldberg MV","year":"2011","journal-title":"Curr Top Microbiol Immunol"}],"container-title":["Asia-Pacific Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajco.13730","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajco.13730","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajco.13730","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T16:20:26Z","timestamp":1692807626000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajco.13730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,30]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1111\/ajco.13730"],"URL":"https:\/\/doi.org\/10.1111\/ajco.13730","archive":["Portico"],"relation":{},"ISSN":["1743-7555","1743-7563"],"issn-type":[{"value":"1743-7555","type":"print"},{"value":"1743-7563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,30]]},"assertion":[{"value":"2021-08-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}