{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T19:48:53Z","timestamp":1788983333172,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,1,30]],"date-time":"2022-01-30T00:00:00Z","timestamp":1643500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with early\u2010onset colorectal cancer (EO\u2010CRC) have unique characteristics. Contemporary data on the pathological and molecular features, and survival of EO\u2010CRC are limited in the Australian context.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the demographic, histopathological and molecular characteristics of adults with EO\u2010CRC, and their survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective study of adults aged 18\u201349 years with EO\u2010CRC who were referred to the Illawarra Shoalhaven Local Health District, South Eastern Sydney Local Health District and Royal North Shore Hospital in New South Wales, Australia, between 2014 and 2018.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 257 patients included, 94 (37%) patients presented with de novo metastatic CRC, 80% patients had near\u2010average risk family history and 89% had a symptomatic presentation. In 159 patients with nonmetastatic disease at diagnosis, stage III disease (OR 3.88 [95% CI: 1.13\u201313.3]; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.03) and the presence of perineural invasion (PNI) (OR 6.63 [95% CI: 2.21\u201319.84]; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.001) were risk factors associated with the development of metastatic disease. Among 94 patients with de novo metastatic disease, 43 (43%) and 12 (14%) patients harbored a <jats:italic>KRAS<\/jats:italic> or <jats:italic>BRAF<\/jats:italic> V600E mutation, respectively. The median overall survival was 29.6 months (95% CI: 20.4\u201338.7). <jats:italic>BRAF<\/jats:italic> mutation was associated with inferior survival (HR 3.00 [95% CI: 1.30\u20136.94]; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of <jats:italic>KRAS<\/jats:italic> and <jats:italic>BRAF<\/jats:italic> mutations in our cohort is similar to the overseas experience. Stage III disease at diagnosis, presence of PNI and <jats:italic>BRAF<\/jats:italic> mutation are adverse prognostic indicators. A better understanding of the molecular landscape is needed for this patient cohort, so as to better tailor prevention strategies, screening and treatment pathways.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.13745","type":"journal-article","created":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T04:13:56Z","timestamp":1643602436000},"page":"660-668","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinical and molecular profile of young adults with early\u2010onset colorectal cancer: Experience from four Australian tertiary centers"],"prefix":"10.1111","volume":"18","author":[{"given":"Derrick Ho Wai","family":"Siu","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Illawarra Shoalhaven Local Health District (ISLHD)  New South Wales Australia"},{"name":"Department of Medical Oncology St George Hospital  New South Wales Australia"},{"name":"National Health and Medical Research Council 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