{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:14:14Z","timestamp":1792088054790,"version":"4.4.0"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T00:00:00Z","timestamp":1652918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study examined the associations of body mass index (BMI) and weight change with inflammatory markers among breast cancer survivors in Korea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 495 women were included who had been diagnosed with primary breast cancer and survived for at least 6 months since the surgery. Information on the body weight and height of the participants was collected both at the study enrollment and diagnosis. The plasma levels of inflammatory markers were measured, including high\u2010sensitivity C\u2010reactive protein, interleukin (IL)\u20106, IL\u20108, tumor necrosis factor\u2010\u03b1, and adiponectin. A summary z\u2010score was calculated by summing up the z\u2010scores of each biomarker. The least\u2010square means and 95% confidence intervals (CIs) were calculated using a generalized linear model and odds ratios (ORs) and 95% CIs for the elevated levels of inflammatory markers with a multivariate logistic regression model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Participants with a BMI \u226527.5\u00a0kg\/m<jats:sup>2<\/jats:sup> at the study enrollment and at diagnosis were significantly associated with elevated summary z\u2010scores compared to those with a BMI\u00a0&lt;\u00a023\u00a0kg\/m<jats:sup>2<\/jats:sup>; the ORs (95% CIs) were 5.42 (2.15\u201313.71) for current BMI and 3.66 (1.68\u20137.98) for BMI at diagnosis, respectively. Additionally, a weight loss\u00a0&gt;\u00a05% since diagnosis was associated with a lower prevalence of high summary z\u2010scores; the OR (95% CI) was .20 (.08\u2013.52) compared to a stable weight.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A high BMI at diagnosis and current BMI with a greater degree were associated with unfavorable levels of inflammatory markers among breast cancer survivors. Additionally, weight loss since diagnosis was inversely associated with these markers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.13779","type":"journal-article","created":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T04:53:46Z","timestamp":1653022426000},"page":"113-125","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Associations of body mass index and weight change with circulating levels of high\u2010sensitivity C\u2010reactive protein, proinflammatory cytokines, and adiponectin among breast cancer survivors"],"prefix":"10.1111","volume":"19","author":[{"given":"Hyun Jeong","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Food and Nutrition, College of Human Ecology Seoul National University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sihan","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, College of Human Ecology Seoul National University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zisun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery Soonchunhyang University Bucheon Hospital  Bucheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Jo","family":"Youn","sequence":"additional","affiliation":[{"name":"Department of Surgery Jeonbuk National University Medical School  Jeonju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihyoung","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Surgery Keimyung University School of Medicine  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Won","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Surgery College of Medicine, Dankook University  Cheonan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoo Seok","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery College of Medicine, Chosun University  Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang\u2010Woon","family":"Choi","sequence":"additional","affiliation":[{"name":"Chaum Life Center CHA University  Seoul Republic of Korea"},{"name":"Department of Nutrition School of Public Health and Health Sciences University of Massachusetts Amherst  Amherst Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Eun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, College of Human Ecology Seoul National University  Seoul Republic of Korea"},{"name":"Research Institute of Human Ecology Seoul National University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2020.206"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu042"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv275"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/EdBook_AM.2013.33.46"},{"issue":"9","key":"e_1_2_12_7_1","first-page":"17715","article-title":"Prognostic role of C\u2010reactive protein in breast cancer: an updated systematic review and meta\u2010analysis","volume":"9","author":"Guo L","year":"2016","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01058.2004"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-008-0207-2"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1079\/PNS2001110"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-015-0741-4"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.100363"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12003"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/253580"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2004.11.007"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-008-9985-5"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-12-343"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-13-0852"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnci.2015.09.001"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12190"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-20-1029"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000052939.59093.45"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.3109\/1354750X.2016.1160431"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1758-5996-3-23"},{"issue":"3","key":"e_1_2_12_25_1","first-page":"156","article-title":"Obesity\u2010related markers and breast cancer in CPS\u2010II Nutrition Cohort","volume":"4","author":"Gaudet MM","year":"2013","journal-title":"Int J Mol Epidemiol Genet"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04517.x"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e31821ece12"},{"key":"e_1_2_12_28_1","first-page":"1","article-title":"Development of a FFQ for breast cancer survivors in Korea","volume":"15","author":"Shin WK","year":"2016","journal-title":"Br J Nutr"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)15268-3"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020135"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.61.6375"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jada.2011.10.022"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2010.513803"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20245"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-012-0104-x"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-19-1572"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.020578"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1879-4"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.5301\/tj.5000357"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2018.10.002"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.06.017"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00110.2003"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(03)00090-1"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-978684"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M500294-JLR200"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802407"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1079\/BJN20041213"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05485"}],"container-title":["Asia-Pacific Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajco.13779","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajco.13779","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajco.13779","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T23:15:57Z","timestamp":1692573357000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajco.13779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,19]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1111\/ajco.13779"],"URL":"https:\/\/doi.org\/10.1111\/ajco.13779","archive":["Portico"],"relation":{},"ISSN":["1743-7555","1743-7563"],"issn-type":[{"value":"1743-7555","type":"print"},{"value":"1743-7563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,19]]},"assertion":[{"value":"2021-10-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}