{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T17:56:14Z","timestamp":1775238974278,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,5,22]],"date-time":"2022-05-22T00:00:00Z","timestamp":1653177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The MEAM regimen consisting of ranimustine (MCNU), etoposide (ETP), cytarabine (Ara\u2010C), and melphalan (MEL) is widely used before auto\u2010peripheral blood stem cell transplantation (auto\u2010PBSCT) for malignant lymphoma in Japan. The MEAM regimen generally consists of 200\u2013400\u00a0mg\/m<jats:sup>2<\/jats:sup> for 4 days, but we decided to increase the dosage of Ara\u2010C from the standard to 2\u00a0g\/m<jats:sup>2<\/jats:sup> for 2 days with the aim of increasing drug transferability to the central nervous system. We evaluate the safety and therapeutic efficacy of high\u2010dose Ara\u2010C MEAM therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The high\u2010dose Ara\u2010C MEAM protocol consisted of MCNU 300\u00a0mg\/m<jats:sup>2<\/jats:sup> on day \u20137, ETP 200\u00a0mg\/m<jats:sup>2<\/jats:sup> on days \u20136, \u20135, \u20134, \u20133 and Ara\u2010C 2\u00a0g\/m<jats:sup>2<\/jats:sup> on day \u20134 \u20133, and MEL 140\u00a0mg\/m<jats:sup>2<\/jats:sup> on day \u20132. We retrospectively analyzed 37 cases of malignant lymphoma at our institution between May 2014 and July 2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients got engraftment and there were no cases of treatment\u2010related mortality. In all cases, the 3\u2010year overall survival (OS) and progression\u2010free survival (PFS) after transplantation were 80.6% and 65.7%, respectively. Twenty\u2010one cases of diffuse large B\u2010cell lymphoma recurrence, for which there is proven usefulness of auto\u2010PBSCT, showed good results after transplantation, with the 3\u2010year OS and PFS after transplantation being 100% and 74.3%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The safety and efficacy of high\u2010dose Ara\u2010C MEAM therapy were demonstrated, but the expected therapeutic effect on central nervous system lesions could not be fully evaluated owing to the small number of cases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.13780","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T06:30:57Z","timestamp":1653287457000},"page":"136-148","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Safety and efficacy of high\u2010dose cytarabine MEAM therapy and other treatments for auto\u2010peripheral blood stem cell 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