{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:36:51Z","timestamp":1747183011371,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T00:00:00Z","timestamp":1662681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The study aimed to evaluate the efficacy and safety of dose\u2010escalated stereotactic body radiotherapy (SBRT) for primary lung cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with peripherally located T1\u20102N0M0 primary lung cancer who underwent SBRT from April 2013 to December 2019 were included. Group A received 60\u00a0Gy in five fractions with CyberKnife prescribed at 99% gross tumor volume. Group B received 48\u00a0Gy in four fractions by a gantry\u2010mounted linear accelerator, with isocenter prescription. Cumulative incidence of local failure (LF), progression free survival (PFS), overall survival (OS), and toxicity were retrospectively compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Groups A and B comprised 39 and 36 patients, respectively. Group A had more patients without histological confirmation (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) and showed lower V20 of bilateral lungs (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.025). The median follow\u2010up duration of Group A and B was 22.0 and 21.5 months, respectively, and the 2\u2010year cumulative incidence of LF, PFS, and OS were .0%\u00a0versus 11.6% (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.065), 66.2%\u00a0versus 62.7% (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.694), 84.1%\u00a0versus 81.1% (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.827), respectively. There was no difference in Grade \u2265 2 toxicity rate between Groups A and B (7.7%\u00a0vs. 11.1%; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.704).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Dose\u2010escalated SBRT using CyberKnife showed reduced lung dose and potential benefits for improved local control with comparable toxicity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.13842","type":"journal-article","created":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T03:09:50Z","timestamp":1662779390000},"page":"320-326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Potential benefit of dose\u2010escalated stereotactic body radiation therapy using CyberKnife for early\u2010stage primary lung cancer"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8893-0653","authenticated-orcid":false,"given":"Shou","family":"Watanabe","sequence":"first","affiliation":[{"name":"Department of Radiology, Graduate School of Medical Science Kyoto Prefectural University of Medicine  Kamigyo\u2010ku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideya","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Radiology, Graduate School of Medical Science Kyoto Prefectural University of Medicine  Kamigyo\u2010ku Japan"},{"name":"CyberKnife Center Soseikai Clinic  Fushimi\u2010ku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Kimoto","sequence":"additional","affiliation":[{"name":"Department of Radiology, Graduate School of Medical Science Kyoto Prefectural University of Medicine  Kamigyo\u2010ku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroya","family":"Shiomi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Graduate School of Medical Science Kyoto Prefectural University of Medicine  Kamigyo\u2010ku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Radiology, Graduate School of Medical Science Kyoto Prefectural University of Medicine  Kamigyo\u2010ku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gen","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Radiology, Graduate School of Medical Science Kyoto Prefectural University of Medicine  Kamigyo\u2010ku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.261"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.11.042"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2007.10.017"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(01)02731-6"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2015.07.2260"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.02.087"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2015.07.2278"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/31372149"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.5306\/wjco.v10.i1.14"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2016.11.002"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2018.1481292"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e318074de34"},{"key":"e_1_2_10_14_1","first-page":"277","article-title":"A randomized phase III trial of comparing two dose\u2010fractionations stereotactic body radiotherapy (SBRT) for medically inoperable stage IA non\u2010small cell lung cancer or small lung lesions clinically diagnosed as primary lung cancer: Japan clinical oncology group study JCOG1408 (J\u2010SBRT trial)","volume":"47","author":"Kimura T","year":"2017","journal-title":"Jpn J Clin Oncol"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2008.04.005"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2019.07.008"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jrr\/rrw096"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2017.05.012"},{"key":"e_1_2_10_19_1","first-page":"1","article-title":"ICRU report 91. 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