{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T13:17:13Z","timestamp":1720617433021},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:00:00Z","timestamp":1666310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the change in signal intensity (SI) and volume (V) from multiparametric magnetic resonance imaging (MRI) for assessing the response of locally advanced rectal cancer (LARC) to chemoradiotherapy (CRT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Eight\u2010two LARC patients who underwent pre\u2010 and post\u2010CRT T2\u2010weighted (T2W), apparent diffusion coefficient (ADC), and contrast\u2010enhanced T1\u2010weighted (ceT1W) MRI were retrospectively analyzed. The change of volume (%\u25b3V) and relative SI ratio (%\u25b3SIR) from each sequence were determined. All LARCs were confirmed pathologically and classified as tumor regression grade (TRG) \u20100, 1, 2,or 3. Descriptive statistics and receiver operating characteristic (ROC) analysis, with calculation of area under the curve (AUC), were used to compare the diagnostic performances.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixteen patients had TRG\u20100, 15 had TRG\u20101, 35 had TRG\u20102, and 16 had TRG\u20103. Except for ADC\u2010%\u25b3SIR, the remaining %\u25b3V and %\u25b3SIR values on MR sequences had significant differences among the four groups. The %\u25b3V and %\u25b3SIR (alone or together) did not distinguish TRG\u20101 from TRG\u20102, nor TRG\u20102 from TRG\u20103; however, differences between other TRGs were identified by %\u25b3V and %\u25b3SIR. The combined use of ADC\u2010%\u25b3V and T2W\u2010%\u25b3SIR provided the best diagnostic performance in distinguishing of TRG\u20100 from TRG\u20102 (AUC: 0.954) and from TRG\u20103 (AUC: 1.000).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Preoperative MRI of LARC patients after CRT has high diagnostic value for determination TRG, and may therefore improve the selection of patients most suitable for surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.13878","type":"journal-article","created":{"date-parts":[[2022,10,22]],"date-time":"2022-10-22T06:23:25Z","timestamp":1666419805000},"page":"327-336","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of the diagnostic performance of changes in signal intensity and volume from multiparametric MRI for assessing response of rectal cancer to neoadjuvant 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