{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T20:41:07Z","timestamp":1780951267087,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T00:00:00Z","timestamp":1671494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recommendations for surveillance imaging for resected melanoma vary considerably. This study examined the utility of imaging in patients with a high\u2010risk primary melanoma undergoing a protocolized imaging schedule.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study involved data collection regarding imaging, recurrence, and outcome characteristics for patients referred to the Victorian Melanoma Service from January 2016\u2013April 2020 and managed for resected stage IIC or III melanoma. Patients with a T4b tumor who did not undergo a sentinel lymph node biopsy were included (T4bNX). Recurrences were \u201cclinically detected\u201d if they were primarily detected by patient symptoms or physical examination, or \u2018imaging\u2010detected\u2019 if the patient was asymptomatic. Cox regression models including time\u2010varying co\u2010variates were used to assess the impact of imaging\u2010detected versus clinically\u2010detected recurrence on overall survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over a median follow\u2010up time of 2.7 years, 199 patients underwent surveillance imaging (T4bNX:22, IIC:33, IIIA:22, IIIB:60, IIIC:61, IIID:1), and 44% (<jats:italic>n<\/jats:italic>\u00a0=\u00a088) experienced disease recurrence. Imaging detected over half (53%) of all recurrences. In adjusted analyses, mortality risk was reduced after an imaging\u2010detected compared to clinically\u2010detected recurrence at any given time from the start of surveillance (hazard ratio 0.25, 95% confidence interval 0.10\u20130.66, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study indicates that routine imaging in the early follow\u2010up period of resected T4bNX, stage IIC and III melanoma plays an important role in the detection of asymptomatic recurrences. Imaging\u2010detected recurrence may be associated with a survival benefit and studies with more prolonged follow\u2010up are required to confirm these findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.13913","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T06:29:35Z","timestamp":1671604175000},"page":"566-573","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The role of surveillance imaging for resected high\u2010risk melanoma"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4700-3781","authenticated-orcid":false,"given":"Mabel K.","family":"Yan","sequence":"first","affiliation":[{"name":"Victorian Melanoma Service Alfred Health  Melbourne Australia"},{"name":"School of Public Health and Preventive Medicine Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikki R.","family":"Adler","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rory","family":"Wolfe","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Pan","sequence":"additional","affiliation":[{"name":"Victorian Melanoma Service Alfred Health  Melbourne Australia"},{"name":"Central Clinical School Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Chamberlain","sequence":"additional","affiliation":[{"name":"Victorian Melanoma Service Alfred Health  Melbourne Australia"},{"name":"Central Clinical School Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Kelly","sequence":"additional","affiliation":[{"name":"Victorian Melanoma Service Alfred Health  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Yap","sequence":"additional","affiliation":[{"name":"Central Clinical School Monash University  Melbourne Australia"},{"name":"Department of Nuclear Medicine and PET Alfred Health  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Voskoboynik","sequence":"additional","affiliation":[{"name":"Central Clinical School Monash University  Melbourne Australia"},{"name":"Department of Medical Oncology Alfred Health  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Haydon","sequence":"additional","affiliation":[{"name":"Central Clinical School Monash University  Melbourne Australia"},{"name":"Department of Medical Oncology Alfred Health  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Shackleton","sequence":"additional","affiliation":[{"name":"Central Clinical School Monash University  Melbourne Australia"},{"name":"Department of Medical Oncology Alfred Health  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria J.","family":"Mar","sequence":"additional","affiliation":[{"name":"Victorian Melanoma Service Alfred Health  Melbourne Australia"},{"name":"School of Public Health and Preventive Medicine Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5642-0"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2019.0440"},{"key":"e_1_2_11_4_1","first-page":"1465","article-title":"Systemic treatments for metastatic cutaneous melanoma","volume":"2","author":"Crosby T","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1709684"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31601-X"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1904059"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30578-2"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature22079"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.08.055"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2019.11.014"},{"key":"e_1_2_11_12_1","unstructured":"Cancer Council Australia Melanoma Guidelines Working Party. 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