{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:36:57Z","timestamp":1747183017863,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T00:00:00Z","timestamp":1678665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to evaluate the safety and efficacy of <jats:sup>131<\/jats:sup>I\u2010rituximab in patients with relapsed or refractory follicular or mantle cell lymphoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010four patients with relapsed or refractory follicular or mantle cell lymphoma were administered unlabeled rituximab (70\u00a0mg) immediately before receiving a therapeutic dose of <jats:sup>131<\/jats:sup>I\u2010rituximab. Contrast\u2010enhanced 18F\u2010fluorodeoxyglucose positron emission tomography\/computed tomography was used a month later to assess tumor response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This study enrolled 24 patients between June 2012 and 2022. Depending on how they responded to radioimmunotherapy (RIT), <jats:sup>131<\/jats:sup>I\u2010rituximab was administered one to five times. Of the 24 patients, 9 achieved complete response after RIT and 8 achieved partial response. The median progression\u2010free and overall survival was 5.9 and 37.9 months, respectively. During the follow\u2010up period of 64.2 months, three patients were diagnosed with a secondary malignancy. Among treatment\u2010related adverse events, hematologic toxicities were common, and grade 3\u20134 thrombocytopenia and neutropenia were reported in 66.6% of cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:sup>131<\/jats:sup>I\u2010rituximab has an effective and favorable safety profile in patients with relapsed or refractory follicular lymphoma and mantle cell lymphoma. This suggests that RIT may also be considered a treatment option for patients with relapsed or refractory follicular lymphoma and mantle cell lymphoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.13932","type":"journal-article","created":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T06:11:02Z","timestamp":1678774262000},"page":"690-696","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Radioimmunotherapy with <sup>131<\/sup>I\u2010rituximab for patients with relapsed or refractory follicular or mantle cell lymphoma"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5186-136X","authenticated-orcid":false,"given":"Yoon Jung","family":"Jang","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology, Korea Cancer Center Hospital Korea Institute of Radiological and Medical Sciences  Seoul Republic of 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